FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082320681> ?p ?o ?g. }

• W2082320681 endingPage "e1004449" @default.
• W2082320681 startingPage "e1004449" @default.
• W2082320681 abstract "During oogenesis, the egg prepares for fertilization and early embryogenesis. As a consequence, vesicle transport is very active during vitellogenesis, and oocytes are an outstanding system to study regulators of membrane trafficking. Here, we combine zebrafish genetics and the oocyte model to identify the molecular lesion underlying the zebrafish souffle (suf) mutation. We demonstrate that suf encodes the homolog of the Hereditary Spastic Paraplegia (HSP) gene SPASTIZIN (SPG15). We show that in zebrafish oocytes suf mutants accumulate Rab11b-positive vesicles, but trafficking of recycling endosomes is not affected. Instead, we detect Suf/Spastizin on cortical granules, which undergo regulated secretion. We demonstrate genetically that Suf is essential for granule maturation into secretion competent dense-core vesicles describing a novel role for Suf in vesicle maturation. Interestingly, in suf mutants immature, secretory precursors accumulate, because they fail to pinch-off Clathrin-coated buds. Moreover, pharmacological inhibition of the abscission regulator Dynamin leads to an accumulation of immature secretory granules and mimics the suf phenotype. Our results identify a novel regulator of secretory vesicle formation in the zebrafish oocyte. In addition, we describe an uncharacterized cellular mechanism for Suf/Spastizin activity during secretion, which raises the possibility of novel therapeutic avenues for HSP research." @default.
• W2082320681 created "2016-06-24" @default.
• W2082320681 creator A5009682495 @default.
• W2082320681 creator A5019760246 @default.
• W2082320681 creator A5027861606 @default.
• W2082320681 creator A5034761572 @default.
• W2082320681 creator A5054318485 @default.
• W2082320681 creator A5076335922 @default.
• W2082320681 creator A5090609842 @default.
• W2082320681 date "2014-06-26" @default.
• W2082320681 modified "2023-09-25" @default.
• W2082320681 title "Souffle/Spastizin Controls Secretory Vesicle Maturation during Zebrafish Oogenesis" @default.
• W2082320681 cites W1481214469 @default.
• W2082320681 cites W1485367438 @default.
• W2082320681 cites W1499176799 @default.
• W2082320681 cites W1513555193 @default.
• W2082320681 cites W1516827048 @default.
• W2082320681 cites W1548405860 @default.
• W2082320681 cites W1574748879 @default.
• W2082320681 cites W1603151752 @default.
• W2082320681 cites W178269644 @default.
• W2082320681 cites W1970318944 @default.
• W2082320681 cites W1972089739 @default.
• W2082320681 cites W1972631011 @default.
• W2082320681 cites W1973908590 @default.
• W2082320681 cites W1973988284 @default.
• W2082320681 cites W1975962457 @default.
• W2082320681 cites W1976377553 @default.
• W2082320681 cites W1980124652 @default.
• W2082320681 cites W1981026057 @default.
• W2082320681 cites W1981424690 @default.
• W2082320681 cites W1981431290 @default.
• W2082320681 cites W1983046843 @default.
• W2082320681 cites W1985252531 @default.
• W2082320681 cites W1986665005 @default.
• W2082320681 cites W1990713759 @default.
• W2082320681 cites W1993656784 @default.
• W2082320681 cites W1997598750 @default.
• W2082320681 cites W2000491758 @default.
• W2082320681 cites W2003665687 @default.
• W2082320681 cites W2005406123 @default.
• W2082320681 cites W2006585409 @default.
• W2082320681 cites W2007118279 @default.
• W2082320681 cites W2008142268 @default.
• W2082320681 cites W2008146810 @default.
• W2082320681 cites W2010995825 @default.
• W2082320681 cites W2014667804 @default.
• W2082320681 cites W2016266703 @default.
• W2082320681 cites W2020020555 @default.
• W2082320681 cites W2022387762 @default.
• W2082320681 cites W2023404116 @default.
• W2082320681 cites W2026360271 @default.
• W2082320681 cites W2029018363 @default.
• W2082320681 cites W2034226518 @default.
• W2082320681 cites W2036229899 @default.
• W2082320681 cites W2042787144 @default.
• W2082320681 cites W2043291430 @default.
• W2082320681 cites W2046133662 @default.
• W2082320681 cites W2052489620 @default.
• W2082320681 cites W2057685263 @default.
• W2082320681 cites W2062070852 @default.
• W2082320681 cites W2063518159 @default.
• W2082320681 cites W2065042047 @default.
• W2082320681 cites W2065226275 @default.
• W2082320681 cites W2065365365 @default.
• W2082320681 cites W2067486032 @default.
• W2082320681 cites W2069291325 @default.
• W2082320681 cites W2070326039 @default.
• W2082320681 cites W2070472792 @default.
• W2082320681 cites W2076313803 @default.
• W2082320681 cites W2077686137 @default.
• W2082320681 cites W2084234612 @default.
• W2082320681 cites W2086271423 @default.
• W2082320681 cites W2087176961 @default.
• W2082320681 cites W2090851195 @default.
• W2082320681 cites W2091564856 @default.
• W2082320681 cites W2091599508 @default.
• W2082320681 cites W2093410495 @default.
• W2082320681 cites W2094507386 @default.
• W2082320681 cites W2094544368 @default.
• W2082320681 cites W2094711984 @default.
• W2082320681 cites W2095121578 @default.
• W2082320681 cites W2096829751 @default.
• W2082320681 cites W2097556771 @default.
• W2082320681 cites W2099719055 @default.
• W2082320681 cites W2106869704 @default.
• W2082320681 cites W2108941359 @default.
• W2082320681 cites W2109672926 @default.
• W2082320681 cites W2111411308 @default.
• W2082320681 cites W2112032807 @default.
• W2082320681 cites W2115373693 @default.
• W2082320681 cites W2116558029 @default.
• W2082320681 cites W2126733007 @default.
• W2082320681 cites W2127326086 @default.
• W2082320681 cites W2133007496 @default.
• W2082320681 cites W2134390983 @default.
• W2082320681 cites W2137540320 @default.
• W2082320681 cites W2137999618 @default.

• next