FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082321819> ?p ?o ?g. }

• W2082321819 endingPage "101" @default.
• W2082321819 startingPage "93" @default.
• W2082321819 abstract "In the brain, neurons and glial cells compete for the uptake of the fast neurotransmitters, glutamate, GABA and glycine, through specific transporters. The relative contributions of glia and neurons to the neurotransmitter uptake depend on the kinetic properties, thermodynamic coupling and density of transporters but also on the intracellular metabolization or sequestration of the neurotransmitter. In the case of glycine, which is both an inhibitory transmitter and a neuromodulator of the excitatory glutamatergic transmission as a co-agonist of N-methyl D-aspartate receptors, the glial (GlyT1b) and neuronal (GlyT2a) transporters differ at least in three aspects: (i) stoichiometries, (ii) reverse uptake capabilities and (iii) pre-steady-state kinetics. A 3 Na+/1 Cl−/gly stoichiometry was established for GlyT2a on the basis of a 2 charges/glycine flux ratio and changes in the reversal potential of the transporter current as a function of the extracellular glycine, Na+ and Cl− concentrations. Therefore, the driving force available for glycine uphill transport in neurons is about two orders of magnitude larger than for glial cells. In addition, GlyT2a shows a severe limitation for reverse uptake, which suggests an essential role of GlyT2a in maintaining a high intracellular glycine pool, thus facilitating the refilling of synaptic vesicles by the low affinity, low specificity vesicular transporter VGAT/VIAAT. In contrast, the 2 Na+/1 Cl−/gly stoichiometry and bi-directional transport properties of GlyT1b are appropriate for the control of the extracellular glycine concentration in a submicromolar range that can modulate N-methyl D-aspartate receptors effectively. Finally, analysis of the pre-steady-state kinetics of GlyT1b and GlyT2a revealed that at the resting potential neuronal transporters are preferentially oriented outward, ready to bind glycine, which suggests a kinetic advantage in the uptake contest." @default.
• W2082321819 created "2016-06-24" @default.
• W2082321819 creator A5001802304 @default.
• W2082321819 creator A5024560348 @default.
• W2082321819 date "2002-08-28" @default.
• W2082321819 modified "2023-10-14" @default.
• W2082321819 title "Why glycine transporters have different stoichiometries" @default.
• W2082321819 cites W113694765 @default.
• W2082321819 cites W1244863148 @default.
• W2082321819 cites W1505732106 @default.
• W2082321819 cites W1533091812 @default.
• W2082321819 cites W1553149131 @default.
• W2082321819 cites W1559268142 @default.
• W2082321819 cites W1559658775 @default.
• W2082321819 cites W1588629441 @default.
• W2082321819 cites W1597054100 @default.
• W2082321819 cites W1600455132 @default.
• W2082321819 cites W1618487358 @default.
• W2082321819 cites W1626546769 @default.
• W2082321819 cites W1646272776 @default.
• W2082321819 cites W1788084167 @default.
• W2082321819 cites W1833075442 @default.
• W2082321819 cites W1839965102 @default.
• W2082321819 cites W1852646540 @default.
• W2082321819 cites W1860158865 @default.
• W2082321819 cites W1897919376 @default.
• W2082321819 cites W1911169303 @default.
• W2082321819 cites W1938064199 @default.
• W2082321819 cites W1957270349 @default.
• W2082321819 cites W1966217930 @default.
• W2082321819 cites W1966846060 @default.
• W2082321819 cites W1967130109 @default.
• W2082321819 cites W1967192722 @default.
• W2082321819 cites W1972161610 @default.
• W2082321819 cites W1973351968 @default.
• W2082321819 cites W1974073599 @default.
• W2082321819 cites W1974517858 @default.
• W2082321819 cites W1975715220 @default.
• W2082321819 cites W1977084918 @default.
• W2082321819 cites W1977203567 @default.
• W2082321819 cites W1977445837 @default.
• W2082321819 cites W1977634657 @default.
• W2082321819 cites W1979412071 @default.
• W2082321819 cites W1981111905 @default.
• W2082321819 cites W1983084616 @default.
• W2082321819 cites W1984272093 @default.
• W2082321819 cites W1991394229 @default.
• W2082321819 cites W1992680999 @default.
• W2082321819 cites W1992792117 @default.
• W2082321819 cites W1993391624 @default.
• W2082321819 cites W1994364763 @default.
• W2082321819 cites W1995691299 @default.
• W2082321819 cites W1996122552 @default.
• W2082321819 cites W1998041728 @default.
• W2082321819 cites W1998478437 @default.
• W2082321819 cites W1999612489 @default.
• W2082321819 cites W2002367189 @default.
• W2082321819 cites W2002779643 @default.
• W2082321819 cites W2013845069 @default.
• W2082321819 cites W2014493691 @default.
• W2082321819 cites W2014793858 @default.
• W2082321819 cites W2018149549 @default.
• W2082321819 cites W2020483119 @default.
• W2082321819 cites W2026348045 @default.
• W2082321819 cites W2027965057 @default.
• W2082321819 cites W2028263308 @default.
• W2082321819 cites W2028604388 @default.
• W2082321819 cites W2028962276 @default.
• W2082321819 cites W2030352252 @default.
• W2082321819 cites W2037860929 @default.
• W2082321819 cites W2040708509 @default.
• W2082321819 cites W2049879893 @default.
• W2082321819 cites W2050453104 @default.
• W2082321819 cites W2050529989 @default.
• W2082321819 cites W2053739364 @default.
• W2082321819 cites W2055690117 @default.
• W2082321819 cites W2056960549 @default.
• W2082321819 cites W2060224220 @default.
• W2082321819 cites W2060584495 @default.
• W2082321819 cites W2060890290 @default.
• W2082321819 cites W2062146488 @default.
• W2082321819 cites W2062928716 @default.
• W2082321819 cites W2065192682 @default.
• W2082321819 cites W2066562577 @default.
• W2082321819 cites W2066871393 @default.
• W2082321819 cites W2066902435 @default.
• W2082321819 cites W2069049686 @default.
• W2082321819 cites W2069466082 @default.
• W2082321819 cites W2070065790 @default.
• W2082321819 cites W2073302688 @default.
• W2082321819 cites W2073703547 @default.
• W2082321819 cites W2075853825 @default.
• W2082321819 cites W2076481913 @default.
• W2082321819 cites W2078310394 @default.
• W2082321819 cites W2079382471 @default.
• W2082321819 cites W2081678712 @default.
• W2082321819 cites W2082768478 @default.
• W2082321819 cites W2085519854 @default.

• next