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• W2082328144 abstract "The novel cytokine melanoma differentiation associated gene-7 (mda-7) was identified by subtractive hybridization in the mid-1990s as a protein whose expression increased during the induction of terminal differentiation, and that was either not expressed or was present at low levels in tumor cells compared with non-transformed cells. On the basis of conserved structure, chromosomal location and cytokine-like properties, MDA-7, has now been classified as a member of the expanding interleukin (IL)-10 gene family and designated as MDA-7/IL-24. Multiple studies have shown that the expression of MDA-7/IL-24 in a wide variety of tumor cell types, but not in the corresponding equivalent non-transformed cells, causes their growth arrest and ultimately cell death. In addition, MDA-7/IL-24 has been noted to be a radiosensitizing cytokine, which is partly because of the generation of reactive oxygen species and ceramide that cause endoplasmic reticulum stress. Phase I clinical trial data has shown that a recombinant adenovirus expressing MDA-7/IL-24 [Ad.mda-7 (INGN-241)] was safe and had measurable tumoricidal effects in over 40% of patients, which strongly argues that MDA-7/IL-24 may have significant therapeutic value. This review describes what is known about the impact of MDA-7/IL-24 on tumor cell biology and its potential therapeutic applications." @default.
• W2082328144 created "2016-06-24" @default.
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• W2082328144 date "2010-09-01" @default.
• W2082328144 modified "2023-10-06" @default.
• W2082328144 title "MDA-7/IL-24 as a cancer therapeutic: from bench to bedside" @default.
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• W2082328144 doi "https://doi.org/10.1097/cad.0b013e32833cfbe1" @default.
• W2082328144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2915543" @default.
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• W2082328144 hasPublicationYear "2010" @default.
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