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- W2082330596 abstract "Abstract— The effect of L-2,4 diaminobutyric acid (DABA) and β-alanine on the K+ stimulated release of [3H]GABA was examined using a continuous superfusion system in which a carrier mediated exchange diffusion could be demonstrated between [3H]GABA in preloaded rat cortical slices and unlabeled DABA and β-alanine in the superfusion medium. These structurally related amino acids were chosen to investigate the source of releasable [3H]GABA because of evidence suggesting they may have differing affinities for the GABA carrier transport system that are specific for neurons and glia, DABA having a greater affinity for the neuronal GABA system and β-alanine for the glial. Five millimolars-DABA in the superfusion medium nearly abolished the K+ stimulated release of [3H]GABA whereas β-alanine had little effect. The results and conclusions are discussed in terms of a postulated carrier mediated exchange of unlabeled DABA with a specific neuronal pool of [3H]GABA interfering with the K+ stimulated release of the radiolabeled GABA. The results provide indirect evidence in favor of a neuronal pool as the source of releasable [3H]GABA in this system." @default.
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- W2082330596 date "1976-08-01" @default.
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- W2082330596 title "RELEASE OF [<sup>3</sup>H]GABA FROM RAT CORTICAL SLICES: NEURONAL VS GLIAL ORIGIN" @default.
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- W2082330596 doi "https://doi.org/10.1111/j.1471-4159.1976.tb12260.x" @default.
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