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• W2082332151 endingPage "530" @default.
• W2082332151 startingPage "520" @default.
• W2082332151 abstract "The typical symptoms of schizophrenia (SZ) are psychotic symptoms (hallucinations, delusions, disorders of thought or speech, grossly disorganized behavior) as well as cognitive impairments and negative symptoms. Not all patients respond to treatment and in those who do, only psychotic symptoms are usually improved. Imaging studies have shown that SZ subjects with high striatal dopamine release are far more responsive to antipsychotic drugs than those patients who have dopamine levels lower than or comparable to that of normal controls. In the present study we hypothesized that there was a link between psychosis and the number of dopaminergic synapses in the caudate nucleus in SZ. We examined dopaminergic synapses at the electron microscopic level in postmortem caudate from cases obtained from the Maryland Brain Collection. SZs were subdivided based on treatment response or resistance. The tissue was processed for the immunocytochemical localization of tyrosine hydroxylase (TH), the synthesizing enzyme for dopamine, and prepared for electron microscopy. The density of all TH labeled synapses was 43% greater in treatment responders than in controls and 62% greater in than in treatment resistant SZ. Axodendritic, but not axospinous, TH-labeled synapses showed this increase. TH-labeled axodendritic synapses in treatment responders were elevated in density (1.95 +/- 0.093/10 microm(3)) compared to treatment resistant SZ (0.04 +/- 0.017/10 microm(3)) and controls (0.11 +/- 0.044/10 microm(3)). The results of the present study suggest that one anatomical underpinning of good treatment response may be a higher density of dopaminergic synapses and support a biological basis to treatment response and resistance. Moreover, these data have important implications for linking specific neuropathology with particular symptoms." @default.
• W2082332151 created "2016-06-24" @default.
• W2082332151 creator A5001439788 @default.
• W2082332151 creator A5005809766 @default.
• W2082332151 creator A5018010521 @default.
• W2082332151 creator A5034093325 @default.
• W2082332151 date "2009-06-01" @default.
• W2082332151 modified "2023-10-06" @default.
• W2082332151 title "Dopaminergic synapses in the caudate of subjects with schizophrenia: Relationship to treatment response" @default.
• W2082332151 cites W1499413566 @default.
• W2082332151 cites W1546941611 @default.
• W2082332151 cites W1625996387 @default.
• W2082332151 cites W177664770 @default.
• W2082332151 cites W1806613378 @default.
• W2082332151 cites W1857277871 @default.
• W2082332151 cites W1964684181 @default.
• W2082332151 cites W1965403083 @default.
• W2082332151 cites W1965714279 @default.
• W2082332151 cites W1966460145 @default.
• W2082332151 cites W1972345009 @default.
• W2082332151 cites W1973253580 @default.
• W2082332151 cites W1974520523 @default.
• W2082332151 cites W1974608989 @default.
• W2082332151 cites W1975435280 @default.
• W2082332151 cites W1978991192 @default.
• W2082332151 cites W1979359907 @default.
• W2082332151 cites W1980016842 @default.
• W2082332151 cites W1988829918 @default.
• W2082332151 cites W1993929326 @default.
• W2082332151 cites W1994639520 @default.
• W2082332151 cites W1994978840 @default.
• W2082332151 cites W1996327177 @default.
• W2082332151 cites W2000834048 @default.
• W2082332151 cites W2001334798 @default.
• W2082332151 cites W2002414447 @default.
• W2082332151 cites W2004101827 @default.
• W2082332151 cites W2005466129 @default.
• W2082332151 cites W2006475955 @default.
• W2082332151 cites W2009447429 @default.
• W2082332151 cites W2011308923 @default.
• W2082332151 cites W2013921912 @default.
• W2082332151 cites W2014355239 @default.
• W2082332151 cites W2014898006 @default.
• W2082332151 cites W2020439765 @default.
• W2082332151 cites W2026408490 @default.
• W2082332151 cites W2028183577 @default.
• W2082332151 cites W2029430017 @default.
• W2082332151 cites W2029607371 @default.
• W2082332151 cites W2032284808 @default.
• W2082332151 cites W2032410067 @default.
• W2082332151 cites W2036691108 @default.
• W2082332151 cites W2039732315 @default.
• W2082332151 cites W2042160923 @default.
• W2082332151 cites W2042329023 @default.
• W2082332151 cites W2046291435 @default.
• W2082332151 cites W2047662014 @default.
• W2082332151 cites W2048024033 @default.
• W2082332151 cites W2048646915 @default.
• W2082332151 cites W2050130096 @default.
• W2082332151 cites W2052651441 @default.
• W2082332151 cites W2054265484 @default.
• W2082332151 cites W2056692846 @default.
• W2082332151 cites W2063167199 @default.
• W2082332151 cites W2064392759 @default.
• W2082332151 cites W2065432160 @default.
• W2082332151 cites W2067217122 @default.
• W2082332151 cites W2070850322 @default.
• W2082332151 cites W2071857109 @default.
• W2082332151 cites W2076140644 @default.
• W2082332151 cites W2077312665 @default.
• W2082332151 cites W2085291810 @default.
• W2082332151 cites W2085899483 @default.
• W2082332151 cites W2090829912 @default.
• W2082332151 cites W2091690930 @default.
• W2082332151 cites W2092820864 @default.
• W2082332151 cites W2096542244 @default.
• W2082332151 cites W2097801108 @default.
• W2082332151 cites W2102248966 @default.
• W2082332151 cites W2106875648 @default.
• W2082332151 cites W2108968692 @default.
• W2082332151 cites W2112630389 @default.
• W2082332151 cites W2121300736 @default.
• W2082332151 cites W2123417323 @default.
• W2082332151 cites W2124497126 @default.
• W2082332151 cites W2125272641 @default.
• W2082332151 cites W2134441514 @default.
• W2082332151 cites W2150760506 @default.
• W2082332151 cites W2159155203 @default.
• W2082332151 cites W2165162816 @default.
• W2082332151 cites W2169490712 @default.
• W2082332151 cites W2287117140 @default.
• W2082332151 cites W4232804908 @default.
• W2082332151 cites W4317929355 @default.
• W2082332151 doi "https://doi.org/10.1002/syn.20623" @default.
• W2082332151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2770250" @default.
• W2082332151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19226604" @default.
• W2082332151 hasPublicationYear "2009" @default.
• W2082332151 type Work @default.

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