Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082352332> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2082352332 endingPage "18" @default.
- W2082352332 startingPage "10" @default.
- W2082352332 abstract "There is continuing and emerging new interest in the development of vitamin D analogs resulting from the recognition that analogs of 1α,25-dihydroxyvitamin D3 [1α,25-(OH)2D3] may be therapeutically useful. Side chain analogs of this steroid hormone are of particular interest because a family of lead structures have recently emerged for possible use in the treatment of certain types of cancers and skin diseases. Because of the chaotic array of side chain structures which exhibit useful therapeutic indices for these purposes, a more systematic approach towards developing intelligible structure-function information needs development. Accordingly, a method has been devised to analyze analogs as to their side chain topology based on identifying specific occupancy volumes through conformational analysis. Dot maps have been constructed as an indication of the volume in space which the side chain of 1α,25-(OH)2-D3 or analogs is permitted to occupy. Volume exclusion analyses based on comparison of structural and biological data for 1α,257-(OH)2-D3 and analogs are anticipated to lead to a more cogent model for drug design. A cautionary note on the limitations of this approach is discussed." @default.
- W2082352332 created "2016-06-24" @default.
- W2082352332 creator A5026648902 @default.
- W2082352332 creator A5033014816 @default.
- W2082352332 creator A5051603352 @default.
- W2082352332 creator A5061428733 @default.
- W2082352332 date "1992-05-01" @default.
- W2082352332 modified "2023-10-15" @default.
- W2082352332 title "Vitamin D: Structure-function analyses and the design of analogs" @default.
- W2082352332 cites W1964548913 @default.
- W2082352332 cites W1966589956 @default.
- W2082352332 cites W1968482816 @default.
- W2082352332 cites W1973120601 @default.
- W2082352332 cites W1976278863 @default.
- W2082352332 cites W1982779013 @default.
- W2082352332 cites W1983342929 @default.
- W2082352332 cites W1985698009 @default.
- W2082352332 cites W1997473658 @default.
- W2082352332 cites W1997747101 @default.
- W2082352332 cites W2003649714 @default.
- W2082352332 cites W2005809544 @default.
- W2082352332 cites W2007266472 @default.
- W2082352332 cites W2011595417 @default.
- W2082352332 cites W2012554934 @default.
- W2082352332 cites W2021564025 @default.
- W2082352332 cites W2031338453 @default.
- W2082352332 cites W2049796734 @default.
- W2082352332 cites W2050159278 @default.
- W2082352332 cites W2056569270 @default.
- W2082352332 cites W2057354512 @default.
- W2082352332 cites W2073956186 @default.
- W2082352332 cites W2076717562 @default.
- W2082352332 cites W2079139557 @default.
- W2082352332 cites W2082318911 @default.
- W2082352332 cites W2095502221 @default.
- W2082352332 cites W2312721620 @default.
- W2082352332 cites W2325431618 @default.
- W2082352332 cites W2430246616 @default.
- W2082352332 cites W36053226 @default.
- W2082352332 cites W4252566640 @default.
- W2082352332 cites W7619323 @default.
- W2082352332 doi "https://doi.org/10.1002/jcb.240490104" @default.
- W2082352332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1644848" @default.
- W2082352332 hasPublicationYear "1992" @default.
- W2082352332 type Work @default.
- W2082352332 sameAs 2082352332 @default.
- W2082352332 citedByCount "59" @default.
- W2082352332 countsByYear W20823523322012 @default.
- W2082352332 countsByYear W20823523322019 @default.
- W2082352332 countsByYear W20823523322020 @default.
- W2082352332 countsByYear W20823523322022 @default.
- W2082352332 crossrefType "journal-article" @default.
- W2082352332 hasAuthorship W2082352332A5026648902 @default.
- W2082352332 hasAuthorship W2082352332A5033014816 @default.
- W2082352332 hasAuthorship W2082352332A5051603352 @default.
- W2082352332 hasAuthorship W2082352332A5061428733 @default.
- W2082352332 hasConcept C14036430 @default.
- W2082352332 hasConcept C178790620 @default.
- W2082352332 hasConcept C185592680 @default.
- W2082352332 hasConcept C204921945 @default.
- W2082352332 hasConcept C41008148 @default.
- W2082352332 hasConcept C521977710 @default.
- W2082352332 hasConcept C70721500 @default.
- W2082352332 hasConcept C71240020 @default.
- W2082352332 hasConcept C86803240 @default.
- W2082352332 hasConcept C95444343 @default.
- W2082352332 hasConceptScore W2082352332C14036430 @default.
- W2082352332 hasConceptScore W2082352332C178790620 @default.
- W2082352332 hasConceptScore W2082352332C185592680 @default.
- W2082352332 hasConceptScore W2082352332C204921945 @default.
- W2082352332 hasConceptScore W2082352332C41008148 @default.
- W2082352332 hasConceptScore W2082352332C521977710 @default.
- W2082352332 hasConceptScore W2082352332C70721500 @default.
- W2082352332 hasConceptScore W2082352332C71240020 @default.
- W2082352332 hasConceptScore W2082352332C86803240 @default.
- W2082352332 hasConceptScore W2082352332C95444343 @default.
- W2082352332 hasIssue "1" @default.
- W2082352332 hasLocation W20823523321 @default.
- W2082352332 hasLocation W20823523322 @default.
- W2082352332 hasOpenAccess W2082352332 @default.
- W2082352332 hasPrimaryLocation W20823523321 @default.
- W2082352332 hasRelatedWork W1531601525 @default.
- W2082352332 hasRelatedWork W1968448361 @default.
- W2082352332 hasRelatedWork W2017201663 @default.
- W2082352332 hasRelatedWork W2606230654 @default.
- W2082352332 hasRelatedWork W2607424097 @default.
- W2082352332 hasRelatedWork W2748952813 @default.
- W2082352332 hasRelatedWork W2899084033 @default.
- W2082352332 hasRelatedWork W2948807893 @default.
- W2082352332 hasRelatedWork W4387497383 @default.
- W2082352332 hasRelatedWork W2778153218 @default.
- W2082352332 hasVolume "49" @default.
- W2082352332 isParatext "false" @default.
- W2082352332 isRetracted "false" @default.
- W2082352332 magId "2082352332" @default.
- W2082352332 workType "article" @default.