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• W2082364273 abstract "Most functional magnetic resonance imaging (fMRI) techniques are sensitive to susceptibility variations and rely on the change in blood oxygenation level in response to neuronal activation (BOLD). The BOLD effect is accompanied by a change in cerebral blood flow (rCBF) and cerebral blood volume (rCBV). Intravascular contrast agents, such as magnetite nanoparticles, can be used to measure changes in rCBV. A new measuring protocol has been developed that enables the separate quantification of changes in blood volume and oxygenation levels. A combination of alternating acoustic stimulation blocks and infusion of a superparamagnetic contrast agent offers the possibility to disentangle the competing influences of oxygenation and blood volume changes. Serial blood sampling during infusion was used to assess the actual contrast agent concentration during infusion in order to calculate absolute blood volume changes during neuronal resting and activation states. Magn Reson Med 42:829–836, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2082364273 date "1999-11-01" @default.
• W2082364273 modified "2023-10-16" @default.
• W2082364273 title "Titration of the BOLD effect: Separation and quantitation of blood volume and oxygenation changes in the human cerebral cortex during neuronal activation and ferumoxide infusion" @default.
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• W2082364273 doi "https://doi.org/10.1002/(sici)1522-2594(199911)42:5<829::aid-mrm2>3.0.co;2-6" @default.
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