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• W2082364497 abstract "Glucocorticoid–glutamatergic interactions have been proposed as a potential model to explain stress-mediated impairment of cognition. However, it is unknown whether glucocorticoid–zincergic interactions are involved in this impairment. Histochemically reactive zinc (Zn2+) is co-released with glutamate from zincergic neurons. In the present study, involvement of synaptic Zn2+ in stress-induced attenuation of CA1 LTP was examined in hippocampal slices from young rats after exposure to tail suspension stress for 30 s, which significantly increased serum corticosterone. Stress-induced attenuation of CA1 LTP was ameliorated by administration of clioquinol, a membrane permeable zinc chelator, to rats prior to exposure to stress, implying that the reduction of synaptic Zn2+ by clioquinol participates in this amelioration. To pursue the involvement of corticosterone-mediated Zn2+ signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn2+ was checked in hippocampal slices exposed to corticosterone. Corticosterone increased extracellular Zn2+ levels measured with ZnAF-2 dose-dependently, as well as the intracellular Ca2+ levels measured with calcium orange AM, suggesting that corticosterone excites zincergic neurons in the hippocampus and increases Zn2+ release from the neuron terminals. Intracellular Zn2+ levels measured with ZnAF-2DA were also increased dose-dependently, but not in the coexistence of CaEDTA, a membrane-impermeable zinc chelator, suggesting that intracellular Zn2+ levels is increased by the influx of extracellular Zn2+. Furthermore, corticosterone-induced attenuation of CA1 LTP was abolished in the coexistence of CaEDTA. The present study suggests that corticosterone-mediated increase in postsynaptic Zn2+ signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress." @default.
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• W2082364497 date "2012-03-01" @default.
• W2082364497 modified "2023-10-18" @default.
• W2082364497 title "Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress" @default.
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• W2082364497 doi "https://doi.org/10.1016/j.neuint.2012.01.021" @default.
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