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• W2082366901 startingPage "e1002012" @default.
• W2082366901 abstract "Microbes within polymicrobial infections often display synergistic interactions resulting in enhanced pathogenesis; however, the molecular mechanisms governing these interactions are not well understood. Development of model systems that allow detailed mechanistic studies of polymicrobial synergy is a critical step towards a comprehensive understanding of these infections in vivo. In this study, we used a model polymicrobial infection including the opportunistic pathogen Aggregatibacter actinomycetemcomitans and the commensal Streptococcus gordonii to examine the importance of metabolite cross-feeding for establishing co-culture infections. Our results reveal that co-culture with S. gordonii enhances the pathogenesis of A. actinomycetemcomitans in a murine abscess model of infection. Interestingly, the ability of A. actinomycetemcomitans to utilize L-lactate as an energy source is essential for these co-culture benefits. Surprisingly, inactivation of L-lactate catabolism had no impact on mono-culture growth in vitro and in vivo suggesting that A. actinomycetemcomitans L-lactate catabolism is only critical for establishing co-culture infections. These results demonstrate that metabolite cross-feeding is critical for A. actinomycetemcomitans to persist in a polymicrobial infection with S. gordonii supporting the idea that the metabolic properties of commensal bacteria alter the course of pathogenesis in polymicrobial communities." @default.
• W2082366901 created "2016-06-24" @default.
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• W2082366901 creator A5043138147 @default.
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• W2082366901 date "2011-03-31" @default.
• W2082366901 modified "2023-10-15" @default.
• W2082366901 title "Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection" @default.
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• W2082366901 doi "https://doi.org/10.1371/journal.ppat.1002012" @default.
• W2082366901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3069116" @default.
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• W2082366901 hasPublicationYear "2011" @default.
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