Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082371387> ?p ?o ?g. }
- W2082371387 abstract "Several studies have suggested a role for blood coagulation proteins in tumour progression. Herein, we discuss (1) the activation of the blood clotting cascade in the tumour microenvironment and its impact on primary tumour growth; (2) the intravascular activation of blood coagulation and its impact on tumour metastasis and cancer-associated thrombosis; and (3) antitumour therapies that target blood-coagulation-associated proteins. Expression levels of the clotting initiator protein TF (tissue factor) have been correlated with tumour cell aggressiveness. Simultaneous TF expression and PS (phosphatidylserine) exposure by tumour cells promote the extravascular activation of blood coagulation. The generation of blood coagulation enzymes in the tumour microenvironment may trigger the activation of PARs (protease-activated receptors). In particular, PAR1 and PAR2 have been associated with many aspects of tumour biology. The procoagulant activity of circulating tumour cells favours metastasis, whereas the release of TF-bearing MVs (microvesicles) into the circulation has been correlated with cancer-associated thrombosis. Given the role of coagulation proteins in tumour progression, it has been proposed that they could be targets for the development of new antitumour therapies." @default.
- W2082371387 created "2016-06-24" @default.
- W2082371387 creator A5056362500 @default.
- W2082371387 creator A5056833266 @default.
- W2082371387 date "2013-09-04" @default.
- W2082371387 modified "2023-10-16" @default.
- W2082371387 title "Activation of blood coagulation in cancer: implications for tumour progression" @default.
- W2082371387 cites W142608924 @default.
- W2082371387 cites W1509894190 @default.
- W2082371387 cites W1572562929 @default.
- W2082371387 cites W1575078254 @default.
- W2082371387 cites W1632264659 @default.
- W2082371387 cites W165853039 @default.
- W2082371387 cites W1805074460 @default.
- W2082371387 cites W1811402656 @default.
- W2082371387 cites W1853739041 @default.
- W2082371387 cites W1881424050 @default.
- W2082371387 cites W1963938486 @default.
- W2082371387 cites W1964473451 @default.
- W2082371387 cites W1966556597 @default.
- W2082371387 cites W1969259882 @default.
- W2082371387 cites W1969327353 @default.
- W2082371387 cites W1969673646 @default.
- W2082371387 cites W1972331749 @default.
- W2082371387 cites W1978080273 @default.
- W2082371387 cites W1979914134 @default.
- W2082371387 cites W1983530319 @default.
- W2082371387 cites W1983999973 @default.
- W2082371387 cites W1984352482 @default.
- W2082371387 cites W1985473224 @default.
- W2082371387 cites W1989077910 @default.
- W2082371387 cites W1994861753 @default.
- W2082371387 cites W1996009186 @default.
- W2082371387 cites W1996514632 @default.
- W2082371387 cites W1998106433 @default.
- W2082371387 cites W1998996776 @default.
- W2082371387 cites W1999429023 @default.
- W2082371387 cites W1999668293 @default.
- W2082371387 cites W2003714769 @default.
- W2082371387 cites W2005500743 @default.
- W2082371387 cites W2005876253 @default.
- W2082371387 cites W2007353543 @default.
- W2082371387 cites W2008409796 @default.
- W2082371387 cites W2008800578 @default.
- W2082371387 cites W2010114725 @default.
- W2082371387 cites W2012535096 @default.
- W2082371387 cites W2015962018 @default.
- W2082371387 cites W2017465156 @default.
- W2082371387 cites W2021254403 @default.
- W2082371387 cites W2026448131 @default.
- W2082371387 cites W2026603823 @default.
- W2082371387 cites W2029738976 @default.
- W2082371387 cites W2032860439 @default.
- W2082371387 cites W2035362880 @default.
- W2082371387 cites W2036999916 @default.
- W2082371387 cites W2037103210 @default.
- W2082371387 cites W2038479057 @default.
- W2082371387 cites W2039568250 @default.
- W2082371387 cites W2040496567 @default.
- W2082371387 cites W2042082129 @default.
- W2082371387 cites W2051678321 @default.
- W2082371387 cites W2051959397 @default.
- W2082371387 cites W2053332000 @default.
- W2082371387 cites W2055792439 @default.
- W2082371387 cites W2056350144 @default.
- W2082371387 cites W2058023007 @default.
- W2082371387 cites W2058252463 @default.
- W2082371387 cites W2059035174 @default.
- W2082371387 cites W2059215414 @default.
- W2082371387 cites W2060529002 @default.
- W2082371387 cites W2060621228 @default.
- W2082371387 cites W2063742002 @default.
- W2082371387 cites W2066541045 @default.
- W2082371387 cites W2066763853 @default.
- W2082371387 cites W2067011387 @default.
- W2082371387 cites W2068655393 @default.
- W2082371387 cites W2068773189 @default.
- W2082371387 cites W2069049795 @default.
- W2082371387 cites W2070117107 @default.
- W2082371387 cites W2071682406 @default.
- W2082371387 cites W2071765062 @default.
- W2082371387 cites W2072594768 @default.
- W2082371387 cites W2073032227 @default.
- W2082371387 cites W2073849350 @default.
- W2082371387 cites W2074016597 @default.
- W2082371387 cites W2074892413 @default.
- W2082371387 cites W2080846452 @default.
- W2082371387 cites W2084743097 @default.
- W2082371387 cites W2086458592 @default.
- W2082371387 cites W2090166013 @default.
- W2082371387 cites W2090903207 @default.
- W2082371387 cites W2091848233 @default.
- W2082371387 cites W2093471926 @default.
- W2082371387 cites W2101137688 @default.
- W2082371387 cites W2101185555 @default.
- W2082371387 cites W2103665067 @default.
- W2082371387 cites W2104262711 @default.
- W2082371387 cites W2111328277 @default.
- W2082371387 cites W2112052543 @default.
- W2082371387 cites W2112853332 @default.