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- W2082374513 abstract "We tested the hypothesis that immunoglobulins directed against a CNS autoantigen, myelin basic protein, may promote remyelination in the course of a chronic, immune-mediated demyelinating disease SJL/J mice infected chronically with Daniel9s strain of Theiler9s virus served as an experimental model of MS. The spinal cords of these mice exhibit extensive primary demyelination and inflammation with minimal spontaneous remyelination. Treatment with whole antiserum or affinity-purified mouse immunoglobulins directed against rat or rabbit myelin basic protein increased new myelin synthesis as measured by quantitative morphometry. Electron microscopy revealed numerous oligodendrocytes in remyelinated CNS lesions and a relative lack of inflammatory cells. Viral antigen persisted in the spinal cord despite enhanced CNS-type remyelination. These findings indicate that immunoglobulins reactive with myelin autoantigens have the potential to promote myelin repair. <b>NEUROLOGY 1996;46: </b> 538-545" @default.
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- W2082374513 date "1996-02-01" @default.
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- W2082374513 title "Immunoglobulins reactive with myelin basic protein promote CNS remyelination" @default.
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- W2082374513 doi "https://doi.org/10.1212/wnl.46.2.538" @default.
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