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• W2082389654 endingPage "e0117546" @default.
• W2082389654 startingPage "e0117546" @default.
• W2082389654 abstract "It is generally accepted that nitric oxide (NO) or its derivatives, reactive nitrogen species (RNS), are involved in the development of Parkinson's disease (PD). Recently, emerging evidence in the study of PD has indicated that protein S-nitrosylation triggers the signaling changes in neurons. In this study, SH-SY5Y cells treated with rotenone were used as a model of neuronal death in PD. The treated cells underwent significant apoptosis, which was accompanied by an increase in intracellular NO in a rotenone dose-dependent manner. The CyDye switch approach was employed to screen for changes in S-nitrosylated (SNO) proteins in response to the rotenone treatment. Seven proteins with increased S-nitrosylation were identified in the treated SH-SY5Y cells, which included proliferating cell nuclear antigen (PCNA). Although PCNA is generally located in the nucleus and participates in DNA replication and repair, significant PCNA was identified in the SH-SY5Y cytosol. Using immunoprecipitation and pull-down approaches, PCNA was found to interact with caspase-9; using mass spectrometry, the two cysteine residues PCNA-Cys81 and -Cys162 were identified as candidate S-nitrosylated residues. In addition, the evidence obtained from in vitro and the cell model studies indicated that the S-nitrosylation of PCNA-Cys81 affected the interaction between PCNA and caspase-9. Furthermore, the interaction of PCNA and caspase-9 partially blocked caspase-9 activation, indicating that the S-nitrosylation of cytosolic PCNA may be a mediator of the apoptotic pathway." @default.
• W2082389654 created "2016-06-24" @default.
• W2082389654 creator A5000922713 @default.
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• W2082389654 date "2015-02-12" @default.
• W2082389654 modified "2023-10-16" @default.
• W2082389654 title "The S-Nitrosylation Status of PCNA Localized in Cytosol Impacts the Apoptotic Pathway in a Parkinson’s Disease Paradigm" @default.
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• W2082389654 doi "https://doi.org/10.1371/journal.pone.0117546" @default.
• W2082389654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326459" @default.
• W2082389654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25675097" @default.
• W2082389654 hasPublicationYear "2015" @default.
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