FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082391638> ?p ?o ?g. }

• W2082391638 endingPage "CR24" @default.
• W2082391638 startingPage "CR19" @default.
• W2082391638 abstract "The role of genetic risk factors in ischemic stroke is unclear. Platelet glycoprotein IIb/IIIa (GpIIb-IIIa) has been implicated in the pathogenesis of ischemic stroke. We sought to evaluate the relationship between the GpIIb/IIIa complex gene polymorphism and ischemic stroke.We investigated the association of the GpIIb/IIIa complex gene polymorphism with stroke risk in 306 patients with acute ischemic stroke and 266 control subjects by determining the GpIIb and GpIIIa genotype from leukocyte DNA by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion, respectively.Compared with controls, more patients presented with coronary heart disease, hypertension, smoking history, and diabetes. In addition, the patients had higher levels of cholesterol and glucose compared with the control subjects. All donors in the GpIIIa (n=572) group expressed the GpIIIa PlA1 (HPA-1 aa) phenotype. There were no significant differences between the HPA-3 genotype (GpIIb) patient distribution (aa=39.9%, ab=41.4%, bb=28.7%) and healthy control subjects (aa=36.1%, ab=35.0%, bb=28.9%) (P=0.580). Among study participants <60 years, there was a significant difference in the HPA-3 genotype distributions of patients (aa=42.9%, ab=19.8%, bb=37.4%) and healthy control subjects (aa=43.3%, ab=38.8%, bb=17.9%) (P=0.007). Furthermore, HPA-3 b/b increased the risk of ischemic stroke >2-fold (P=0.008).The GpIIb Ile/Ser843 gene polymorphism is associated with ischemic stroke among young and middle-aged adults (<60 years), especially males. The GpIIIa PlA1 phenotype has no relationship to ischemic stroke." @default.
• W2082391638 created "2016-06-24" @default.
• W2082391638 creator A5019924930 @default.
• W2082391638 creator A5079717997 @default.
• W2082391638 creator A5088866683 @default.
• W2082391638 date "2012-01-01" @default.
• W2082391638 modified "2023-10-05" @default.
• W2082391638 title "Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age" @default.
• W2082391638 cites W1571953251 @default.
• W2082391638 cites W1972429479 @default.
• W2082391638 cites W1983125300 @default.
• W2082391638 cites W1996946595 @default.
• W2082391638 cites W2004311988 @default.
• W2082391638 cites W2004993161 @default.
• W2082391638 cites W2012063088 @default.
• W2082391638 cites W2021760557 @default.
• W2082391638 cites W2029348404 @default.
• W2082391638 cites W2058099503 @default.
• W2082391638 cites W2078253165 @default.
• W2082391638 cites W2090405981 @default.
• W2082391638 cites W2101917328 @default.
• W2082391638 cites W2104736983 @default.
• W2082391638 cites W2104747897 @default.
• W2082391638 cites W2106186734 @default.
• W2082391638 cites W2118094114 @default.
• W2082391638 cites W2152888111 @default.
• W2082391638 cites W2180318774 @default.
• W2082391638 cites W2614781785 @default.
• W2082391638 cites W3022148767 @default.
• W2082391638 cites W4245860073 @default.
• W2082391638 cites W73224360 @default.
• W2082391638 doi "https://doi.org/10.12659/msm.882195" @default.
• W2082391638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560669" @default.
• W2082391638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22207115" @default.
• W2082391638 hasPublicationYear "2012" @default.
• W2082391638 type Work @default.
• W2082391638 sameAs 2082391638 @default.
• W2082391638 citedByCount "16" @default.
• W2082391638 countsByYear W20823916382013 @default.
• W2082391638 countsByYear W20823916382014 @default.
• W2082391638 countsByYear W20823916382016 @default.
• W2082391638 countsByYear W20823916382017 @default.
• W2082391638 countsByYear W20823916382019 @default.
• W2082391638 countsByYear W20823916382020 @default.
• W2082391638 countsByYear W20823916382022 @default.
• W2082391638 crossrefType "journal-article" @default.
• W2082391638 hasAuthorship W2082391638A5019924930 @default.
• W2082391638 hasAuthorship W2082391638A5079717997 @default.
• W2082391638 hasAuthorship W2082391638A5088866683 @default.
• W2082391638 hasBestOaLocation W20823916382 @default.
• W2082391638 hasConcept C104317684 @default.
• W2082391638 hasConcept C126322002 @default.
• W2082391638 hasConcept C127413603 @default.
• W2082391638 hasConcept C134018914 @default.
• W2082391638 hasConcept C135763542 @default.
• W2082391638 hasConcept C203014093 @default.
• W2082391638 hasConcept C26828662 @default.
• W2082391638 hasConcept C2780645631 @default.
• W2082391638 hasConcept C2780942790 @default.
• W2082391638 hasConcept C3018697912 @default.
• W2082391638 hasConcept C54355233 @default.
• W2082391638 hasConcept C555293320 @default.
• W2082391638 hasConcept C71924100 @default.
• W2082391638 hasConcept C78519656 @default.
• W2082391638 hasConcept C86803240 @default.
• W2082391638 hasConcept C89560881 @default.
• W2082391638 hasConcept C90924648 @default.
• W2082391638 hasConceptScore W2082391638C104317684 @default.
• W2082391638 hasConceptScore W2082391638C126322002 @default.
• W2082391638 hasConceptScore W2082391638C127413603 @default.
• W2082391638 hasConceptScore W2082391638C134018914 @default.
• W2082391638 hasConceptScore W2082391638C135763542 @default.
• W2082391638 hasConceptScore W2082391638C203014093 @default.
• W2082391638 hasConceptScore W2082391638C26828662 @default.
• W2082391638 hasConceptScore W2082391638C2780645631 @default.
• W2082391638 hasConceptScore W2082391638C2780942790 @default.
• W2082391638 hasConceptScore W2082391638C3018697912 @default.
• W2082391638 hasConceptScore W2082391638C54355233 @default.
• W2082391638 hasConceptScore W2082391638C555293320 @default.
• W2082391638 hasConceptScore W2082391638C71924100 @default.
• W2082391638 hasConceptScore W2082391638C78519656 @default.
• W2082391638 hasConceptScore W2082391638C86803240 @default.
• W2082391638 hasConceptScore W2082391638C89560881 @default.
• W2082391638 hasConceptScore W2082391638C90924648 @default.
• W2082391638 hasIssue "1" @default.
• W2082391638 hasLocation W20823916381 @default.
• W2082391638 hasLocation W20823916382 @default.
• W2082391638 hasLocation W20823916383 @default.
• W2082391638 hasLocation W20823916384 @default.
• W2082391638 hasOpenAccess W2082391638 @default.
• W2082391638 hasPrimaryLocation W20823916381 @default.
• W2082391638 hasRelatedWork W1964942170 @default.
• W2082391638 hasRelatedWork W2094479369 @default.
• W2082391638 hasRelatedWork W2353115877 @default.
• W2082391638 hasRelatedWork W2365186396 @default.
• W2082391638 hasRelatedWork W2382415459 @default.
• W2082391638 hasRelatedWork W2410328435 @default.
• W2082391638 hasRelatedWork W2412853806 @default.

• next