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- W2082394860 endingPage "313" @default.
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- W2082394860 abstract "It is well documented that leptin is a circulating hormone that plays a key role in regulating food intake and body weight via its actions on specific hypothalamic nuclei. However, leptin receptors are widely expressed in the CNS, in regions not generally associated with energy homeostasis, such as the hippocampus, cortex and cerebellum. Moreover, evidence is accumulating that leptin has widespread actions in the brain. In particular, recent studies have demonstrated that leptin markedly influences the excitability of hippocampal neurons via its ability to activate large conductance Ca(2+)-activated K(+) (BK) channels, and also to promote long-term depression of excitatory synaptic transmission. Here, we review the evidence supporting a role for this hormone in regulating hippocampal excitability." @default.
- W2082394860 created "2016-06-24" @default.
- W2082394860 creator A5012011678 @default.
- W2082394860 date "2006-08-23" @default.
- W2082394860 modified "2023-10-12" @default.
- W2082394860 title "Leptin: a diverse regulator of neuronal function" @default.
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- W2082394860 doi "https://doi.org/10.1111/j.1471-4159.2006.04205.x" @default.
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