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- W2082400677 abstract "low doses are to be considered, they have to be extrapolated down to the control values. The validity of such an extrapolation is disputable but will be used in the presentation of the problem. The reason it is brought up is that we intend to discuss some genetic consequences of an increased background radiation originating from atomic energy sources. At present the doses are very low, but as all kinds of living organisms will be exposed they cannot be neglected. The extrapolation of the linearity of the dose relation of mutations to low doses presupposes that there is no threshold value beneath which the radiation is ineffective as a mutagen. Consequently, even from very small increases in radiation increases in the rates of mutations are expected. This would disturb the equilibrium of newly arisen and eliminated mutant genes. This a priori expectation presumes that the mutability per unit of radiation is unchanged, but such (for the following reasons) need not necessarily be the case. Timof6eff-Ressovsky (2) showed that the mutability of white locus was different in two stocks of Drosophila melanogaster. The mutation rate of w+-allele from an American stock was nearly twice as large as that of a Russian stock. Lefevre (3) showed that in the yellow locus also similar mutation isoalleles existed. In cases like these the isoallele with the lower mutability needs a higher dose than the more mutable allele to produce the same number of mutations. If an increase in the rate of mutations should be disadvantageous to a population, a change to a less mutable allele would help to keep the original equilibrium between mutations and eliminations. We shall call a decrease in mutability in an environment with higher than normal background radiation a mutational adaptation. The present study will deal with this problem." @default.
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- W2082400677 date "1958-02-01" @default.
- W2082400677 modified "2023-09-27" @default.
- W2082400677 title "Does There Exist Mutational Adaptation to Chronic Irradiation?" @default.
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- W2082400677 doi "https://doi.org/10.2307/3570607" @default.
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