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- W2082413498 abstract "Selective muscle wasting of muscular dystrophies is an enigma. Muscular dystrophies, irrespective of their primary protein defect, exhibit common features of progressive muscle wasting suggesting common secondary signaling pathways maybe responsible for disease progression and selectivity. Understanding these mechanisms is necessary for therapy. The aim of this study was to elucidate secondary biochemical pathways that occur in selective muscle wasting of Miyoshi myopathy. Biopsies of severely affected gastroncnemius and relatively spared hamstring muscles from a Miyoshi myopathy patient, obtained with informed consent, were compared to each other and to 5 normal muscles for: (i) total protein content (ii) actin and myosin levels determined by SDS–PAGE (iii) lipid peroxidation (iv) protein tyrosine nitration and cysteine nitrosylation on western blots and (v) the ubiquitin proteasomal degradation pathway determined on western blots. Results: Total protein of the gastroncnemius muscle was 160 mg/gm tissue, of the hamstring muscle 145 mg/gm tissue and 254 ± 56 mg/gm tissue in normal muscle. Gastrocnemius myosin heavy chain (5-fold) and actin (3.1-fold) were lower than normal. Myofibrillar proteins in hamstring muscle were normal. Lipid peroxidation was higher in myopathic muscle (gastrocnemius-750 TBARS nmols/g protein; hamstring-1724 TBARS nmols/g protein) compared to normal (498 ± 99 TBARS nmols/g protein). Nitro-tyrosyinylated proteins were elevated in gastroncnemius muscle (5-fold), in hamstring muscle (2.3-fold) compared to normal. Nitrosothiolyated proteins were 1.5-fold higher in hamstring muscle, 0.65-fold lower in gastroncnemius muscle than normal. Ubiquitinylated proteins were elevated in myopathic muscle (gastrocnemius – 1.6-fold; hamstring – 2.6-fold) compared to normal. Conclusion: Degradation of myofibrillar proteins is associated with selective and pronounced muscle wasting in Miyoshi myopathy. Nitrotyrosinylated proteins maybe involved in this selectivity." @default.
- W2082413498 created "2016-06-24" @default.
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- W2082413498 date "2009-09-01" @default.
- W2082413498 modified "2023-09-24" @default.
- W2082413498 title "G.P.6.04 Nitric oxide signaling in selective muscle wasting of Miyoshi myopathy" @default.
- W2082413498 doi "https://doi.org/10.1016/j.nmd.2009.06.133" @default.
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