Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082414342> ?p ?o ?g. }
- W2082414342 endingPage "289" @default.
- W2082414342 startingPage "275" @default.
- W2082414342 abstract "This study examined whether cholinergic and monoaminergic dysfunctions in the brain could be related to spatial learning capabilities in 26-month-old, as compared to three-month-old, Long–Evans female rats. Performances were evaluated in the water maze task and used to constitute subgroups with a cluster analysis statistical procedure. In the first experiment (histological approach), the first cluster contained young rats and aged unimpaired rats, the second one aged rats with moderate impairment and the third one aged rats with severe impairment. Aged rats showed a reduced number of choline acetyltransferase- and p75NTR-positive neurons in the nucleus basalis magnocellularis, and choline acetyltransferase-positive neurons in the striatum. In the second experiment (neurochemical approach), the three clusters comprised young rats, aged rats with moderate impairment and aged rats with severe impairment. Alterations related to aging consisted of reduced concentration of acetylcholine, norepinephrine and serotonin in the striatum, serotonin in the occipital cortex, dopamine and norepinephrine in the dorsal hippocampus, and norepinephrine in the ventral hippocampus. In the first experiment, there were significant correlations between water maze performance and the number of; (i) choline acetyltransferase- and p75NTR-positive neurons in the nucleus basalis magnocellularis; (ii) choline acetyltransferase-positive neurons in the striatum and; (iii) p75NTR-positive neurons in the medial septum. In the second experiment, water maze performance was correlated with the concentration of; (i) acetylcholine and serotonin in the striatum; (ii) serotonin and norepinephrine in the dorsal hippocampus; (iii) norepinephrine in the frontoparietal cortex and; (iv) with other functional markers such as the 5-hydroxyindoleacetic acid/serotonin ratio in the striatum, 3,4-dihydroxyphenylacetic acid/dopamine ratio in the dorsal hippocampus, 5-hydroxyindoleacetic acid/serotonin and homovanillic acid/dopamine ratios in the frontoparietal cortex, and 3,4-dihydroxyphenylacetic acid/dopamine ratio in the occipital cortex. The results indicate that cognitive deficits related to aging might involve concomitant alterations of various neurochemical systems in several brain regions such as the striatum, the hippocampus or the cortex. It also seems that these alterations occur in a complex way which, in addition to the loss of cholinergic neurons in the basal forebrain, affects dopaminergic, noradrenergic and serotonergic processes." @default.
- W2082414342 created "2016-06-24" @default.
- W2082414342 creator A5017608017 @default.
- W2082414342 creator A5035203438 @default.
- W2082414342 creator A5041477692 @default.
- W2082414342 creator A5077054526 @default.
- W2082414342 creator A5088875170 @default.
- W2082414342 date "2000-02-01" @default.
- W2082414342 modified "2023-09-30" @default.
- W2082414342 title "Immunohistochemical and neurochemical correlates of learning deficits in aged rats" @default.
- W2082414342 cites W1606587171 @default.
- W2082414342 cites W1635321914 @default.
- W2082414342 cites W195556901 @default.
- W2082414342 cites W1964469142 @default.
- W2082414342 cites W1964698997 @default.
- W2082414342 cites W1965250235 @default.
- W2082414342 cites W1965420525 @default.
- W2082414342 cites W1967315046 @default.
- W2082414342 cites W1967836806 @default.
- W2082414342 cites W1970583029 @default.
- W2082414342 cites W1971685143 @default.
- W2082414342 cites W1972718612 @default.
- W2082414342 cites W1973529564 @default.
- W2082414342 cites W1973670522 @default.
- W2082414342 cites W1973688581 @default.
- W2082414342 cites W1974571141 @default.
- W2082414342 cites W1974931432 @default.
- W2082414342 cites W1975979734 @default.
- W2082414342 cites W1976606839 @default.
- W2082414342 cites W1977725656 @default.
- W2082414342 cites W1977901685 @default.
- W2082414342 cites W1979499179 @default.
- W2082414342 cites W1979858313 @default.
- W2082414342 cites W1983262373 @default.
- W2082414342 cites W1983793840 @default.
- W2082414342 cites W1983901172 @default.
- W2082414342 cites W1983985508 @default.
- W2082414342 cites W1985232500 @default.
- W2082414342 cites W1985927343 @default.
- W2082414342 cites W1987957093 @default.
- W2082414342 cites W1988152811 @default.
- W2082414342 cites W1988795019 @default.
- W2082414342 cites W1990709814 @default.
- W2082414342 cites W1991969511 @default.
- W2082414342 cites W1992377744 @default.
- W2082414342 cites W1992380092 @default.
- W2082414342 cites W1993709327 @default.
- W2082414342 cites W1993859341 @default.
- W2082414342 cites W1994067502 @default.
- W2082414342 cites W1994220216 @default.
- W2082414342 cites W1997065612 @default.
- W2082414342 cites W1998968783 @default.
- W2082414342 cites W2001789121 @default.
- W2082414342 cites W2010030065 @default.
- W2082414342 cites W2010936735 @default.
- W2082414342 cites W2011119678 @default.
- W2082414342 cites W2011648922 @default.
- W2082414342 cites W2011755611 @default.
- W2082414342 cites W2012277777 @default.
- W2082414342 cites W2012933525 @default.
- W2082414342 cites W2016107968 @default.
- W2082414342 cites W2018484249 @default.
- W2082414342 cites W2020510347 @default.
- W2082414342 cites W2021346798 @default.
- W2082414342 cites W2022599922 @default.
- W2082414342 cites W2027009747 @default.
- W2082414342 cites W2028181337 @default.
- W2082414342 cites W2030961741 @default.
- W2082414342 cites W2034386060 @default.
- W2082414342 cites W2034783116 @default.
- W2082414342 cites W2035426975 @default.
- W2082414342 cites W2037532476 @default.
- W2082414342 cites W2041286231 @default.
- W2082414342 cites W2041341404 @default.
- W2082414342 cites W2041601285 @default.
- W2082414342 cites W2042022009 @default.
- W2082414342 cites W2043679564 @default.
- W2082414342 cites W2045211568 @default.
- W2082414342 cites W2045290451 @default.
- W2082414342 cites W2045534445 @default.
- W2082414342 cites W2047663606 @default.
- W2082414342 cites W2048941040 @default.
- W2082414342 cites W2049344364 @default.
- W2082414342 cites W2052211037 @default.
- W2082414342 cites W2052884971 @default.
- W2082414342 cites W2052903119 @default.
- W2082414342 cites W2054262036 @default.
- W2082414342 cites W2056701910 @default.
- W2082414342 cites W2057213191 @default.
- W2082414342 cites W2057463798 @default.
- W2082414342 cites W2057847183 @default.
- W2082414342 cites W2059936575 @default.
- W2082414342 cites W2060334626 @default.
- W2082414342 cites W2061664301 @default.
- W2082414342 cites W2063209112 @default.
- W2082414342 cites W2063842282 @default.
- W2082414342 cites W2064806863 @default.
- W2082414342 cites W2065067523 @default.