Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082436614> ?p ?o ?g. }
- W2082436614 endingPage "272" @default.
- W2082436614 startingPage "267" @default.
- W2082436614 abstract "Although insulin resistance in T2DM (type 2 diabetes mellitus) is usually referred to glucose and lipid metabolism, the question whether such a resistance affects also amino acid and protein metabolism is both relevant and not easy to be answered. Available data indicate a reduced response to insulin in the inhibition of proteolysis at low, near basal hormone levels, whereas such a response appears to be normal at high physiological doses. In most studies in T2DM subjects the stimulation of whole-body protein synthesis in the presence of hyperinsulinemia and euaminoacidemia appears to be normal, although one single study reported lower rates in male T2DM subjects with obesity. The response to insulin of plasma protein synthesis (albumin and fibrinogen) is also normal. However, some metabolic steps of amino acids related to vascular complications (methionine and arginine) exhibit a defective response to insulin in T2DM subjects with nephropathy. In summary, although gross alterations in the response of whole-body protein turnover are not evident in T2DM, specific investigations reveal subtle abnormalities in metabolic steps of selected amino acids. Furthermore, the effects of interaction between diabetes (with the associated insulin resistance) and older age in the pathogenesis of sarcopenia in the elderly deserve more specific studies." @default.
- W2082436614 created "2016-06-24" @default.
- W2082436614 creator A5004920142 @default.
- W2082436614 creator A5014568150 @default.
- W2082436614 creator A5015545582 @default.
- W2082436614 creator A5031869445 @default.
- W2082436614 creator A5033438070 @default.
- W2082436614 creator A5071985025 @default.
- W2082436614 creator A5075506922 @default.
- W2082436614 date "2011-06-01" @default.
- W2082436614 modified "2023-10-15" @default.
- W2082436614 title "Insulin resistance of amino acid and protein metabolism in type 2 diabetes" @default.
- W2082436614 cites W1974266155 @default.
- W2082436614 cites W1977001646 @default.
- W2082436614 cites W1979647910 @default.
- W2082436614 cites W1981107426 @default.
- W2082436614 cites W1998736193 @default.
- W2082436614 cites W2007397474 @default.
- W2082436614 cites W2007937775 @default.
- W2082436614 cites W2011861071 @default.
- W2082436614 cites W2022351209 @default.
- W2082436614 cites W2026307928 @default.
- W2082436614 cites W2041176514 @default.
- W2082436614 cites W2045487212 @default.
- W2082436614 cites W2049481764 @default.
- W2082436614 cites W2049511789 @default.
- W2082436614 cites W2059914132 @default.
- W2082436614 cites W2061963900 @default.
- W2082436614 cites W2071866413 @default.
- W2082436614 cites W2082402917 @default.
- W2082436614 cites W2082582400 @default.
- W2082436614 cites W2097531030 @default.
- W2082436614 cites W2098625377 @default.
- W2082436614 cites W2106492265 @default.
- W2082436614 cites W2106573353 @default.
- W2082436614 cites W2113596742 @default.
- W2082436614 cites W2118576335 @default.
- W2082436614 cites W2119348567 @default.
- W2082436614 cites W2123106337 @default.
- W2082436614 cites W2126624423 @default.
- W2082436614 cites W2129347273 @default.
- W2082436614 cites W2130913523 @default.
- W2082436614 cites W2135669694 @default.
- W2082436614 cites W2136781148 @default.
- W2082436614 cites W2137148373 @default.
- W2082436614 cites W2137394317 @default.
- W2082436614 cites W2140503446 @default.
- W2082436614 cites W2152386173 @default.
- W2082436614 cites W2153229820 @default.
- W2082436614 cites W2162254318 @default.
- W2082436614 cites W2164387542 @default.
- W2082436614 cites W2164818281 @default.
- W2082436614 cites W2165243795 @default.
- W2082436614 cites W2166086710 @default.
- W2082436614 cites W2167227928 @default.
- W2082436614 cites W2167818045 @default.
- W2082436614 cites W2168280281 @default.
- W2082436614 cites W2170109807 @default.
- W2082436614 cites W2170869159 @default.
- W2082436614 cites W2313326603 @default.
- W2082436614 cites W2428602706 @default.
- W2082436614 cites W4232928435 @default.
- W2082436614 cites W4233674626 @default.
- W2082436614 cites W4233996577 @default.
- W2082436614 cites W4243917891 @default.
- W2082436614 cites W4251875059 @default.
- W2082436614 cites W4253421640 @default.
- W2082436614 cites W4254261652 @default.
- W2082436614 doi "https://doi.org/10.1016/j.clnu.2011.02.009" @default.
- W2082436614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21492974" @default.
- W2082436614 hasPublicationYear "2011" @default.
- W2082436614 type Work @default.
- W2082436614 sameAs 2082436614 @default.
- W2082436614 citedByCount "50" @default.
- W2082436614 countsByYear W20824366142012 @default.
- W2082436614 countsByYear W20824366142013 @default.
- W2082436614 countsByYear W20824366142014 @default.
- W2082436614 countsByYear W20824366142015 @default.
- W2082436614 countsByYear W20824366142016 @default.
- W2082436614 countsByYear W20824366142017 @default.
- W2082436614 countsByYear W20824366142018 @default.
- W2082436614 countsByYear W20824366142019 @default.
- W2082436614 countsByYear W20824366142020 @default.
- W2082436614 countsByYear W20824366142021 @default.
- W2082436614 countsByYear W20824366142022 @default.
- W2082436614 countsByYear W20824366142023 @default.
- W2082436614 crossrefType "journal-article" @default.
- W2082436614 hasAuthorship W2082436614A5004920142 @default.
- W2082436614 hasAuthorship W2082436614A5014568150 @default.
- W2082436614 hasAuthorship W2082436614A5015545582 @default.
- W2082436614 hasAuthorship W2082436614A5031869445 @default.
- W2082436614 hasAuthorship W2082436614A5033438070 @default.
- W2082436614 hasAuthorship W2082436614A5071985025 @default.
- W2082436614 hasAuthorship W2082436614A5075506922 @default.
- W2082436614 hasConcept C126322002 @default.
- W2082436614 hasConcept C134018914 @default.
- W2082436614 hasConcept C17093226 @default.
- W2082436614 hasConcept C2777180221 @default.