FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082445955> ?p ?o ?g. }

• W2082445955 endingPage "2027" @default.
• W2082445955 startingPage "2019" @default.
• W2082445955 abstract "Abstract Dihydrodiol dehydrogenase (DDH) is a member of the aldo‐keto reductases superfamily (AKR1C1–AKR1C4), which plays central roles in the metabolism of steroid hormone, prostaglandin and xenobiotics. We have previously detected overexpression of DDH as an indicator of poor prognosis and chemoresistance in human non‐small lung cancer (NSCLC). We also found DDH expression to be closely related to chronic inflammatory conditions. The aim of this study was to investigate the links between inflammation, DDH expression and drug resistance in NSCLC cells. We showed that pro‐inflammatory mediators including interleukin‐6 (IL‐6) could induce AKR1C1/1C2 expression in NSCLC cells and increase cellular resistance to cisplatin and adriamycin. This effect was nullified by Safingol, a protein kinase C inhibitor. Moreover, the expression of AKR1C1/1C2 was inversely correlated to NBS1 and apoptosis‐inducing factor (AIF). We also showed that IL‐6‐induced AKR1C1/1C2 expression and drug resistance were inhibited by wogonin and chrysin, which are major flavonoids in Scutellaria baicalensis , a widely used traditional Chinese and Japanese medicine. In conclusion, this study demonstrated novel links of pro‐inflammatory signals, AKR1C1/1C2 expression and drug resistance in NSCLC. The protein kinase C pathway may play an important role in this process. Overexpression of AKR1C1/1C2 may serve as a marker of chemoresistance. Further studies are warranted to evaluate wogonin and chrysin as a potential adjuvant therapy for drug‐resistant NSCLC, especially for those with AKR1C1/1C2 overexpression. © 2007 Wiley‐Liss, Inc." @default.
• W2082445955 created "2016-06-24" @default.
• W2082445955 creator A5014961277 @default.
• W2082445955 creator A5016453981 @default.
• W2082445955 creator A5030708845 @default.
• W2082445955 creator A5037290375 @default.
• W2082445955 creator A5057843840 @default.
• W2082445955 creator A5058391280 @default.
• W2082445955 creator A5090916100 @default.
• W2082445955 date "2007-01-31" @default.
• W2082445955 modified "2023-10-15" @default.
• W2082445955 title "Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin" @default.
• W2082445955 cites W1521225971 @default.
• W2082445955 cites W1529025359 @default.
• W2082445955 cites W1965037168 @default.
• W2082445955 cites W1972715563 @default.
• W2082445955 cites W1973141016 @default.
• W2082445955 cites W1977085981 @default.
• W2082445955 cites W1978000487 @default.
• W2082445955 cites W1978166647 @default.
• W2082445955 cites W1979347549 @default.
• W2082445955 cites W1982730267 @default.
• W2082445955 cites W1985385147 @default.
• W2082445955 cites W1995423152 @default.
• W2082445955 cites W1999064503 @default.
• W2082445955 cites W2000428769 @default.
• W2082445955 cites W2008577129 @default.
• W2082445955 cites W2024869617 @default.
• W2082445955 cites W2025844136 @default.
• W2082445955 cites W2036285510 @default.
• W2082445955 cites W2037139573 @default.
• W2082445955 cites W2037425199 @default.
• W2082445955 cites W2037725133 @default.
• W2082445955 cites W2043013899 @default.
• W2082445955 cites W2044708716 @default.
• W2082445955 cites W2046874266 @default.
• W2082445955 cites W2052548231 @default.
• W2082445955 cites W2053548596 @default.
• W2082445955 cites W2053671318 @default.
• W2082445955 cites W2056020627 @default.
• W2082445955 cites W2060479161 @default.
• W2082445955 cites W2061285200 @default.
• W2082445955 cites W2065168071 @default.
• W2082445955 cites W2070006942 @default.
• W2082445955 cites W2074564761 @default.
• W2082445955 cites W2083001514 @default.
• W2082445955 cites W2083363260 @default.
• W2082445955 cites W2086144679 @default.
• W2082445955 cites W2087408588 @default.
• W2082445955 cites W2087993487 @default.
• W2082445955 cites W2088830222 @default.
• W2082445955 cites W2115806010 @default.
• W2082445955 cites W2116554142 @default.
• W2082445955 cites W2121465850 @default.
• W2082445955 cites W2123728867 @default.
• W2082445955 cites W2125577882 @default.
• W2082445955 cites W2139853624 @default.
• W2082445955 cites W2150587707 @default.
• W2082445955 cites W2164277862 @default.
• W2082445955 cites W2164425862 @default.
• W2082445955 doi "https://doi.org/10.1002/ijc.22402" @default.
• W2082445955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17266043" @default.
• W2082445955 hasPublicationYear "2007" @default.
• W2082445955 type Work @default.
• W2082445955 sameAs 2082445955 @default.
• W2082445955 citedByCount "93" @default.
• W2082445955 countsByYear W20824459552012 @default.
• W2082445955 countsByYear W20824459552013 @default.
• W2082445955 countsByYear W20824459552014 @default.
• W2082445955 countsByYear W20824459552015 @default.
• W2082445955 countsByYear W20824459552016 @default.
• W2082445955 countsByYear W20824459552017 @default.
• W2082445955 countsByYear W20824459552018 @default.
• W2082445955 countsByYear W20824459552019 @default.
• W2082445955 countsByYear W20824459552020 @default.
• W2082445955 countsByYear W20824459552021 @default.
• W2082445955 countsByYear W20824459552022 @default.
• W2082445955 countsByYear W20824459552023 @default.
• W2082445955 crossrefType "journal-article" @default.
• W2082445955 hasAuthorship W2082445955A5014961277 @default.
• W2082445955 hasAuthorship W2082445955A5016453981 @default.
• W2082445955 hasAuthorship W2082445955A5030708845 @default.
• W2082445955 hasAuthorship W2082445955A5037290375 @default.
• W2082445955 hasAuthorship W2082445955A5057843840 @default.
• W2082445955 hasAuthorship W2082445955A5058391280 @default.
• W2082445955 hasAuthorship W2082445955A5090916100 @default.
• W2082445955 hasConcept C114851261 @default.
• W2082445955 hasConcept C121608353 @default.
• W2082445955 hasConcept C126322002 @default.
• W2082445955 hasConcept C142724271 @default.
• W2082445955 hasConcept C188947578 @default.
• W2082445955 hasConcept C204787440 @default.
• W2082445955 hasConcept C2776914184 @default.
• W2082445955 hasConcept C2778004101 @default.
• W2082445955 hasConcept C2778153525 @default.
• W2082445955 hasConcept C2778559982 @default.
• W2082445955 hasConcept C2779054382 @default.
• W2082445955 hasConcept C2779478871 @default.

• next