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- W2082446171 abstract "In the last decade, considerable evidence as accumulated to support the development of Transient Receptor Potential Vanilloid 1 (TRPV1) antagonists for the treatment of various chronic pain conditions. Whereas there is a widely accepted rationale for the development of TRPV1 antagonists for the treatment of various inflammatory pain conditions, their development for indications of chronic pain, where conditions of tactical, mechanical and spontaneous pain predominate, is less clear. Preclinical localization and expression studies provide a firm foundation for the use of molecules targeting TRPV1 for conditions of bone pain, osteoarthritis and neuropathic pain. Selective TRPV1 antagonists weakly attenuate tactile and mechanical hypersensivity and are partially effective for behavioral and electrophysiological endpoints that incorporate aspects of spontaneous pain. While initial studies with TRPV1 antagonist in normal human subjects indicate a loss of warm thermal perception, clinical studies assessing allelic variants suggests that TRPV1 may mediate other sensory modalities under certain conditions. The focus of this review is to summarize the current perspectives of TRPV1 for the treatment of conditions beyond those with a primary thermal sensitivity." @default.
- W2082446171 created "2016-06-24" @default.
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- W2082446171 date "2012-02-02" @default.
- W2082446171 modified "2023-10-11" @default.
- W2082446171 title "TRPV1 Antagonists and Chronic Pain: Beyond Thermal Perception" @default.
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- W2082446171 cites W1541414763 @default.
- W2082446171 cites W1568124021 @default.
- W2082446171 cites W1649126991 @default.
- W2082446171 cites W1963857381 @default.
- W2082446171 cites W1964925166 @default.
- W2082446171 cites W1966923258 @default.
- W2082446171 cites W1967307095 @default.
- W2082446171 cites W1972354061 @default.
- W2082446171 cites W1974107068 @default.
- W2082446171 cites W1984096754 @default.
- W2082446171 cites W1984144008 @default.
- W2082446171 cites W1986816927 @default.
- W2082446171 cites W1988036253 @default.
- W2082446171 cites W1994777993 @default.
- W2082446171 cites W1995705528 @default.
- W2082446171 cites W2002508551 @default.
- W2082446171 cites W2002612293 @default.
- W2082446171 cites W2004222535 @default.
- W2082446171 cites W2006132476 @default.
- W2082446171 cites W2006726845 @default.
- W2082446171 cites W2011909645 @default.
- W2082446171 cites W2014693947 @default.
- W2082446171 cites W2018630802 @default.
- W2082446171 cites W2020588358 @default.
- W2082446171 cites W2022386219 @default.
- W2082446171 cites W2023752710 @default.
- W2082446171 cites W2026842778 @default.
- W2082446171 cites W2028166367 @default.
- W2082446171 cites W2029342741 @default.
- W2082446171 cites W2030711769 @default.
- W2082446171 cites W2033576768 @default.
- W2082446171 cites W2034813908 @default.
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- W2082446171 cites W2050781058 @default.
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- W2082446171 cites W2065687666 @default.
- W2082446171 cites W2066559312 @default.
- W2082446171 cites W2069220320 @default.
- W2082446171 cites W2071564618 @default.
- W2082446171 cites W2075072901 @default.
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- W2082446171 cites W2104726039 @default.
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- W2082446171 doi "https://doi.org/10.3390/ph5020114" @default.
- W2082446171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3763634" @default.
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- W2082446171 hasPublicationYear "2012" @default.
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