FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082449342> ?p ?o ?g. }

• W2082449342 abstract "Abstract Background The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders. Although artemisinin-based combination therapy has been recommended for the treatment of multidrug-resistant falciparum malaria, these combinations are not available for some people, such as travelers from North America. A fixed-dose combination of atovaquone and proguanil (Malarone) has been proved to be effective for the treatment and prophylaxis of malaria which is already approved by countries in North America and Europe. Determination of the phenotypes and genotypes related to atovaquone/proguanil response in Thai isolates of P. falciparum will be useful for rationale drug use. The main purpose of this study was to explore the in vitro atovaquone/proguanil susceptibility of recently adapted Thai isolates of P. falciparum . Genotypic characterization of the cytb gene of these isolates was also determined since it has been reported that point mutations, particularly codon 268 in the cytochrome b gene ( cytb ) have been linked to atovaquone/proguanil treatment failure. Methods Eighty three P. falciparum isolates collected during 1998 to 2005 from four different multidrug resistance areas of Thailand were determined for the in vitro atovaquone/proguanil susceptibilities using radioisotopic assay. Mutations in the cytb gene were determined by PCR-RFLP and sequence analysis. Results The mean atovaquone and proguanil IC 50 was 3.4 nM and 36.5 μM, respectively. All 83 Thai isolates were atovaquone sensitive. None of the 83 isolates contained the mutations at codon 268 of the cytb gene. DNA sequencing of the cytb gene of 20 parasite isolates showed no other mutations. Conclusion In agreement with a recent efficacy study of atovaquone/proguanil, the present information indicates that atovaquone/proguanil can be one of the drugs of choice for the treatment and prophylaxis of multidrug-resistant falciparum malaria in Thailand." @default.
• W2082449342 created "2016-06-24" @default.
• W2082449342 creator A5020255311 @default.
• W2082449342 creator A5063320243 @default.
• W2082449342 creator A5065169507 @default.
• W2082449342 date "2008-01-28" @default.
• W2082449342 modified "2023-10-13" @default.
• W2082449342 title "In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand" @default.
• W2082449342 cites W1962039507 @default.
• W2082449342 cites W1969503178 @default.
• W2082449342 cites W2025495623 @default.
• W2082449342 cites W2025605230 @default.
• W2082449342 cites W2028704380 @default.
• W2082449342 cites W2031908013 @default.
• W2082449342 cites W2034305146 @default.
• W2082449342 cites W2040250193 @default.
• W2082449342 cites W2051563506 @default.
• W2082449342 cites W2082456955 @default.
• W2082449342 cites W2094260046 @default.
• W2082449342 cites W2096756868 @default.
• W2082449342 cites W2101397647 @default.
• W2082449342 cites W2104243533 @default.
• W2082449342 cites W2105668259 @default.
• W2082449342 cites W2107824584 @default.
• W2082449342 cites W2108973475 @default.
• W2082449342 cites W2118259278 @default.
• W2082449342 cites W2124133990 @default.
• W2082449342 cites W2145537179 @default.
• W2082449342 cites W2154834224 @default.
• W2082449342 cites W2162514075 @default.
• W2082449342 cites W2166721999 @default.
• W2082449342 cites W2440933376 @default.
• W2082449342 doi "https://doi.org/10.1186/1475-2875-7-23" @default.
• W2082449342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2265725" @default.
• W2082449342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18226262" @default.
• W2082449342 hasPublicationYear "2008" @default.
• W2082449342 type Work @default.
• W2082449342 sameAs 2082449342 @default.
• W2082449342 citedByCount "24" @default.
• W2082449342 countsByYear W20824493422013 @default.
• W2082449342 countsByYear W20824493422014 @default.
• W2082449342 countsByYear W20824493422015 @default.
• W2082449342 countsByYear W20824493422017 @default.
• W2082449342 countsByYear W20824493422018 @default.
• W2082449342 countsByYear W20824493422019 @default.
• W2082449342 countsByYear W20824493422020 @default.
• W2082449342 countsByYear W20824493422021 @default.
• W2082449342 countsByYear W20824493422023 @default.
• W2082449342 crossrefType "journal-article" @default.
• W2082449342 hasAuthorship W2082449342A5020255311 @default.
• W2082449342 hasAuthorship W2082449342A5063320243 @default.
• W2082449342 hasAuthorship W2082449342A5065169507 @default.
• W2082449342 hasBestOaLocation W20824493421 @default.
• W2082449342 hasConcept C159047783 @default.
• W2082449342 hasConcept C203014093 @default.
• W2082449342 hasConcept C2776120307 @default.
• W2082449342 hasConcept C2778048844 @default.
• W2082449342 hasConcept C2778371730 @default.
• W2082449342 hasConcept C2779124865 @default.
• W2082449342 hasConcept C2779636613 @default.
• W2082449342 hasConcept C71924100 @default.
• W2082449342 hasConcept C86803240 @default.
• W2082449342 hasConceptScore W2082449342C159047783 @default.
• W2082449342 hasConceptScore W2082449342C203014093 @default.
• W2082449342 hasConceptScore W2082449342C2776120307 @default.
• W2082449342 hasConceptScore W2082449342C2778048844 @default.
• W2082449342 hasConceptScore W2082449342C2778371730 @default.
• W2082449342 hasConceptScore W2082449342C2779124865 @default.
• W2082449342 hasConceptScore W2082449342C2779636613 @default.
• W2082449342 hasConceptScore W2082449342C71924100 @default.
• W2082449342 hasConceptScore W2082449342C86803240 @default.
• W2082449342 hasIssue "1" @default.
• W2082449342 hasLocation W20824493421 @default.
• W2082449342 hasLocation W20824493422 @default.
• W2082449342 hasLocation W20824493423 @default.
• W2082449342 hasLocation W20824493424 @default.
• W2082449342 hasOpenAccess W2082449342 @default.
• W2082449342 hasPrimaryLocation W20824493421 @default.
• W2082449342 hasRelatedWork W1901559508 @default.
• W2082449342 hasRelatedWork W1962039507 @default.
• W2082449342 hasRelatedWork W1985750241 @default.
• W2082449342 hasRelatedWork W2000230526 @default.
• W2082449342 hasRelatedWork W2007374716 @default.
• W2082449342 hasRelatedWork W2016307598 @default.
• W2082449342 hasRelatedWork W2085895144 @default.
• W2082449342 hasRelatedWork W2089939861 @default.
• W2082449342 hasRelatedWork W2805546692 @default.
• W2082449342 hasRelatedWork W3093189850 @default.
• W2082449342 hasVolume "7" @default.
• W2082449342 isParatext "false" @default.
• W2082449342 isRetracted "false" @default.
• W2082449342 magId "2082449342" @default.
• W2082449342 workType "article" @default.