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• W2082466970 abstract "Background: Therapeutic peptides and proteins are being increasingly explored as potential therapeutic agents for molecular-targeted therapy, and the requirement for quantitative bioanalytical tools for such molecules has been discussed. Results: The distribution of octreotide, a synthetic octapeptide analog of somatostatin, in the liver and kidney of mice administered with the analog was clearly visualized by MALDI-Imaging MS (IMS). The developed MALDI-IMS analytical method successfully quantified the amount of octreotide on tissue sections (accuracy was 76–127%) and the 2,5-dihydroxybenzoic acid-based normalization method was effective. Conclusion: The results of this study suggest that MALDI-IMS enables the quantification of an administered therapeutic peptide on biological tissue sections, as well as visualization of the in vivo distribution of the peptide." @default.
• W2082466970 created "2016-06-24" @default.
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• W2082466970 date "2013-03-01" @default.
• W2082466970 modified "2023-09-24" @default.
• W2082466970 title "Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS" @default.
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• W2082466970 doi "https://doi.org/10.4155/bio.13.13" @default.
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