FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082474120> ?p ?o ?g. }

• W2082474120 endingPage "129" @default.
• W2082474120 startingPage "124" @default.
• W2082474120 abstract "Although randomized control trials (RCTs) are the ‘gold standard’ to evaluate treatment effects in health care, they are frequently not practical, ethical or politically acceptable in the evaluation of many health system or public health interventions. A good examplewhere a health system intervention has undergone evaluation using an RCT design is the universal health insurance scheme, Seguro Popular, in Mexico. However, this is a rare exception mainly due to the academic background of the Mexican Health Minister, Julio Frenk, who introduced the scheme. More frequently, randomization is not feasible or practical, particularly when interventions target whole or large subgroups of populations. Because of political considerations, policy makers often want to implement changes quickly and refuse to wait several years to determine a new intervention’s effects. Further, they may be reluctant to be seen to withhold an intervention from a particular community, as was the case with the SureStart programme, which aimed to improve health and educational outcomes in young children in the UK. RCTs may also be unethical where clear evidence of benefit has been demonstrated from observational studies, as was the case with cervical cancer screening. Additionally, lack of funding often poses a hurdle to formal evaluation through an RCT, as RCTs can be very costly to carry out. In the absence of an RCT, evaluations often use quasi-experimental designs such as a pre-post study design with measurements before and after the intervention period. Figure 1, panel A shows an introductory example with an outcome measure subject to a secular time trend and an intervention without any impact. The standard approach to detect a significant impact would apply a t-test to compare the means of the preintervention phase with the post-intervention data. However, a t-test does not consider time but simply separates the data into two groups. In the example in panel A of Figure 1, the t-test would obtain a significant p-value although the difference is not due to the intervention but rather captures the secular time trend. In settings with a secular trend, a t-test (or another statistical test) is prone to false positives, as illustrated in the example, and false negatives in case of a negative secular trend. An interrupted time series (ITS) in contrast, adjusts for secular time trends and should be used instead. Panel B of Figure 1 contains a new data set with an intervention affecting the outcome. An ITS is a segmental linear regression model; preintervention and post-intervention are each modeled as a linear regression. Based on an ITS, a secular trend can therefore be captured in the regression line as shown in panel B of Figure 1. An ITS compares the intercept and slope of the regression line before the intervention with the intercept and slope after intervention. A one-time baseline effect of the intervention without influencing the secular trend can be detected as an intercept change. If the intervention changed the secular trend, there will also be a significant difference in the slope between the two periods. Later, we will see that an ITS also comprises more flexible models. Instead of using an ITS design, many studies use preand post-intervention groups without modeling the secular time trend. Examples include evaluations of major interventions DECLARATIONS" @default.
• W2082474120 created "2016-06-24" @default.
• W2082474120 creator A5014178005 @default.
• W2082474120 creator A5015302801 @default.
• W2082474120 creator A5040957901 @default.
• W2082474120 creator A5061312708 @default.
• W2082474120 creator A5084657632 @default.
• W2082474120 date "2013-04-01" @default.
• W2082474120 modified "2023-10-02" @default.
• W2082474120 title "Disentangling secular trends and policy impacts in health studies: use of interrupted time series analysis" @default.
• W2082474120 cites W1974977139 @default.
• W2082474120 cites W2004563782 @default.
• W2082474120 cites W2059546149 @default.
• W2082474120 cites W2074764246 @default.
• W2082474120 cites W2119566762 @default.
• W2082474120 cites W2125913120 @default.
• W2082474120 cites W2127931825 @default.
• W2082474120 cites W2141871264 @default.
• W2082474120 cites W2162736545 @default.
• W2082474120 cites W2477834368 @default.
• W2082474120 doi "https://doi.org/10.1258/jrsm.2012.110319" @default.
• W2082474120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3618159" @default.
• W2082474120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23564896" @default.
• W2082474120 hasPublicationYear "2013" @default.
• W2082474120 type Work @default.
• W2082474120 sameAs 2082474120 @default.
• W2082474120 citedByCount "13" @default.
• W2082474120 countsByYear W20824741202014 @default.
• W2082474120 countsByYear W20824741202015 @default.
• W2082474120 countsByYear W20824741202018 @default.
• W2082474120 countsByYear W20824741202019 @default.
• W2082474120 countsByYear W20824741202020 @default.
• W2082474120 countsByYear W20824741202021 @default.
• W2082474120 countsByYear W20824741202022 @default.
• W2082474120 countsByYear W20824741202023 @default.
• W2082474120 crossrefType "journal-article" @default.
• W2082474120 hasAuthorship W2082474120A5014178005 @default.
• W2082474120 hasAuthorship W2082474120A5015302801 @default.
• W2082474120 hasAuthorship W2082474120A5040957901 @default.
• W2082474120 hasAuthorship W2082474120A5061312708 @default.
• W2082474120 hasAuthorship W2082474120A5084657632 @default.
• W2082474120 hasBestOaLocation W20824741201 @default.
• W2082474120 hasConcept C105795698 @default.
• W2082474120 hasConcept C112197492 @default.
• W2082474120 hasConcept C118552586 @default.
• W2082474120 hasConcept C119857082 @default.
• W2082474120 hasConcept C127313418 @default.
• W2082474120 hasConcept C143724316 @default.
• W2082474120 hasConcept C144024400 @default.
• W2082474120 hasConcept C149782125 @default.
• W2082474120 hasConcept C149923435 @default.
• W2082474120 hasConcept C151406439 @default.
• W2082474120 hasConcept C151730666 @default.
• W2082474120 hasConcept C2522767166 @default.
• W2082474120 hasConcept C27415008 @default.
• W2082474120 hasConcept C2780089965 @default.
• W2082474120 hasConcept C2909024267 @default.
• W2082474120 hasConcept C33923547 @default.
• W2082474120 hasConcept C41008148 @default.
• W2082474120 hasConcept C71924100 @default.
• W2082474120 hasConceptScore W2082474120C105795698 @default.
• W2082474120 hasConceptScore W2082474120C112197492 @default.
• W2082474120 hasConceptScore W2082474120C118552586 @default.
• W2082474120 hasConceptScore W2082474120C119857082 @default.
• W2082474120 hasConceptScore W2082474120C127313418 @default.
• W2082474120 hasConceptScore W2082474120C143724316 @default.
• W2082474120 hasConceptScore W2082474120C144024400 @default.
• W2082474120 hasConceptScore W2082474120C149782125 @default.
• W2082474120 hasConceptScore W2082474120C149923435 @default.
• W2082474120 hasConceptScore W2082474120C151406439 @default.
• W2082474120 hasConceptScore W2082474120C151730666 @default.
• W2082474120 hasConceptScore W2082474120C2522767166 @default.
• W2082474120 hasConceptScore W2082474120C27415008 @default.
• W2082474120 hasConceptScore W2082474120C2780089965 @default.
• W2082474120 hasConceptScore W2082474120C2909024267 @default.
• W2082474120 hasConceptScore W2082474120C33923547 @default.
• W2082474120 hasConceptScore W2082474120C41008148 @default.
• W2082474120 hasConceptScore W2082474120C71924100 @default.
• W2082474120 hasIssue "4" @default.
• W2082474120 hasLocation W20824741201 @default.
• W2082474120 hasLocation W20824741202 @default.
• W2082474120 hasLocation W20824741203 @default.
• W2082474120 hasLocation W20824741204 @default.
• W2082474120 hasOpenAccess W2082474120 @default.
• W2082474120 hasPrimaryLocation W20824741201 @default.
• W2082474120 hasRelatedWork W1970379503 @default.
• W2082474120 hasRelatedWork W2043764402 @default.
• W2082474120 hasRelatedWork W2110132657 @default.
• W2082474120 hasRelatedWork W2140339747 @default.
• W2082474120 hasRelatedWork W2554355744 @default.
• W2082474120 hasRelatedWork W2562266625 @default.
• W2082474120 hasRelatedWork W2906471315 @default.
• W2082474120 hasRelatedWork W2917905779 @default.
• W2082474120 hasRelatedWork W3090550755 @default.
• W2082474120 hasRelatedWork W3124239304 @default.
• W2082474120 hasVolume "106" @default.
• W2082474120 isParatext "false" @default.
• W2082474120 isRetracted "false" @default.

• next