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• W2082486398 abstract "Chronic (8- to 10-week) administration of the selective, potent, and irreversible monoamine oxidase B inhibitor (R)-deprenyl has been shown to increase the tyrosine hydroxylase immunoreactivity in the substantia nigra of mice that had been treated three days earlier with a neurotoxic dose of the parkinsonian-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This reported rescuing of lesioned nigrostriatal cell bodies by (R)-deprenyl prompted us to investigate if this (R)-deprenyl treatment also could restore neostriatal dopamine levels that are depleted by MPTP. The results of these experiments show that long term (8 or 10 weeks) treatment with (R)-deprenyl beginning three days post MPTP administration did not result in restoration of depleted neostriatal dopamine levels in C57BL/6 mice. We conclude that, although (R)-deprenyl may rescue MPTP-injured nigrostriatal neurons, it does not lead to functional recovery of these neurons as measured by the restoration of neostriatal dopamine levels." @default.
• W2082486398 created "2016-06-24" @default.
• W2082486398 creator A5070099912 @default.
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• W2082486398 date "2006-01-25" @default.
• W2082486398 modified "2023-09-24" @default.
• W2082486398 title "Rescue of Dying Neurons by (R)-Deprenyl in the MPTP-Mouse Model of Parkinson's Disease Does Not Include Restoration of Neostriatal Dopamine" @default.
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• W2082486398 doi "https://doi.org/10.1111/j.1749-6632.2001.tb03642.x" @default.
• W2082486398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11462789" @default.
• W2082486398 hasPublicationYear "2006" @default.
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