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- W2082495848 abstract "Acrolein is a highly reactive hazardous air pollutant of human health concern, particularly as it is a component of cigarette smoke. It can be metabolized by enzymes including the aldo-keto reductase (AKR) family of enzymes. AKR7A1 is a member of the AKR7 sub-family and can catalyse the reduction of toxic aldehydes, including α-unsaturated carbonyl compounds, to alcohols [Biochem. J. 312 (1995) 535]. In this study, the role of AKR7A1 in protecting against acrolein toxicity has been assessed by stably-expressing a cDNA encoding AKR7A1 in Chinese hamster V79 cells. Cells expressing AKR7A1 showed over 2-fold increased resistance to acrolein compared to V79 cells alone, as measured by 3-[4,4-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays. IC50 increased from 45 μM in control V79-pCI-neo cells to 125 μM for V79-AKR7A1 cells. Cells expressing AKR7A1 were also found to be less susceptible to DNA damage, showing a decrease in mutation rate in the presence of acrolein as measured by hypoxanthine guanine phosphoribosyl transferase (HGPRT) mutagenicity assays. The mutation rate for acrolein-exposed control cells was 20-fold higher than for acrolein-exposed AKR7A1-expressing cells. These results indicate that AKR7A1 has the potential to protect against acrolein-induced damage in vivo." @default.
- W2082495848 created "2016-06-24" @default.
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- W2082495848 date "2004-03-01" @default.
- W2082495848 modified "2023-09-23" @default.
- W2082495848 title "Detoxication of the environmental pollutant acrolein by a rat liver aldo-keto reductase" @default.
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- W2082495848 doi "https://doi.org/10.1016/j.toxlet.2003.12.056" @default.
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