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• W2082539045 abstract "ABSTRACT: Carboxyfullerenes, including two regioisomers C3 and D3, were investigated as antioxidants against iron-induced oxidative stress in vivo and in vitro. Both C3 and D3 dose-dependently inhibited autoxidation and iron-elevated lipid peroxidation in cortical homogenates. The antioxidative property of C3 was compared to Trolox (a water-soluble analogue of vitamin E) and glutathione. C3 was more effective than glutathione but was less effective than Trolox in inhibiting iron-induced elevation in lipid peroxidation. In urethane-anesthetized rats, intranigral infusion of iron degenerated the nigrostriatal dopaminergic system, including as elevation in lipid peroxidation in the infused substantia nigra (SN) and reductions in K+-evoked dopamine overflow and dopamine content in the ipsilateral striatum 7 days after the infusion. Local application of iron with C3 or D3 prevented iron-induced oxidative injuries. Our data suggest that carboxyfullerenes have a neuroprotective effect in preventing iron-induced oxidative injury in CNS." @default.
• W2082539045 created "2016-06-24" @default.
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• W2082539045 date "1999-12-01" @default.
• W2082539045 modified "2023-09-23" @default.
• W2082539045 title "The Antioxidative Effect of Carboxyfullerenes (C3/D3) on Iron-Induced Oxidative Injury in CNS" @default.
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• W2082539045 doi "https://doi.org/10.1111/j.1749-6632.1999.tb08012.x" @default.
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