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- W2082542003 abstract "Three forms of calf intestine adenosine deaminase were resolved by gel filtrat in Sephacryl C-200 into species of 38,000 (ES), 57,000 (EI) and greater than 200,00 (EL) daltons. The sensitivities of the three forms of adenosine deaminase to the adenosine deaminase inhibitors, 2′-deoxycoformycin (dCF) and erythro-9-(2-hydroxynonyl)adenine (EHNA) were measured. The concentration of inhibitor producing 50% inhibition of EL, EI, and ES was 2 × 10−8 M, 8 × 10−11 M and 2 × 10−11 M, respectively for dCF and 1 × 10−7 M, 3 × 10−10 M and 2 × 10−11 M, respectively, for EHNA. Thus, the ES and EI forms of adenosine deaminase could be distinguished from the EL form the basis of their respective sensitivities to dCF and EHNA." @default.
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- W2082542003 date "1978-11-01" @default.
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- W2082542003 title "Adenosine deaminase inhibitors: Differential effects on multiple forms of adenosine deaminase" @default.
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- W2082542003 doi "https://doi.org/10.1016/s0006-291x(78)80029-1" @default.
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