Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082542680> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2082542680 abstract "In 1978, the National Prostatic Cancer Project launched two protocols evaluating adjuvant therapy after surgery (Protocol 900) or irradiation (Protocol 1000) for clinically localized prostate cancer. All patients underwent staging pelvic lymphadenectomy.After definitive treatment, the patients were randomized either to receive cyclophosphamide 1 g/m2 intravenously every 3 weeks for 2 years or estramustine phosphate 600 mg/m2 orally daily for up to 2 years or to undergo observation only. Patient accession closed in 1985 and includes 184 patients in Protocol 900 (170 evaluable) and 253 in Protocol 1000 (233 evaluable).Lymph node involvement was identified in 198 patients (49% of total), 29% in Protocol 900 and 63% in Protocol 1000. The median progression-free survival (PFS) and survival were greater for patients in Protocol 900 compared with 1000, regardless of the adjuvant therapy. This reflected the greater proportion of patients with lower pathologic stage disease in the surgically treated group. The median PFS was significantly greater for all patients in Protocol 1000 receiving estramustine phosphate adjuvant (48.2 months) compared with patients randomized to receive cyclophosphamide (35.6 months). The median PFS for patients with nodal involvement in Protocol 1000 who received estramustine phosphate adjuvant was prolonged significantly (37.3 months) compared with no treatment (20.9 months). The median PFS for patients with limited nodal disease in Protocol 1000 was longer (39.9 months), regardless of the adjuvant therapy, compared with those with extensive nodal disease (20.7 months). However, in the latter patient group, those receiving adjuvant estramustine phosphate had a significantly longer median PFS (32.8 months) compared with those receiving adjuvant cyclophosphamide (22.7 months) or no adjuvant therapy (12.9 months).Adjuvant estramustine phosphate was beneficial in patients with prostate cancer and pelvic node involvement who received irradiation as definitive treatment." @default.
- W2082542680 created "2016-06-24" @default.
- W2082542680 creator A5025985212 @default.
- W2082542680 creator A5026841294 @default.
- W2082542680 creator A5046567477 @default.
- W2082542680 creator A5085978683 @default.
- W2082542680 date "1993-02-01" @default.
- W2082542680 modified "2023-10-17" @default.
- W2082542680 title "Adjuvant therapy for localized prostate cancer" @default.
- W2082542680 cites W145183620 @default.
- W2082542680 cites W1588009180 @default.
- W2082542680 cites W172850258 @default.
- W2082542680 cites W2003024052 @default.
- W2082542680 cites W2040692069 @default.
- W2082542680 cites W2094412547 @default.
- W2082542680 cites W2396172779 @default.
- W2082542680 cites W2407427318 @default.
- W2082542680 cites W2413125810 @default.
- W2082542680 cites W2416716831 @default.
- W2082542680 cites W2462995286 @default.
- W2082542680 cites W4293241248 @default.
- W2082542680 doi "https://doi.org/10.1002/1097-0142(19930201)71:3+<1005::aid-cncr2820711418>3.0.co;2-i" @default.
- W2082542680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8428323" @default.
- W2082542680 hasPublicationYear "1993" @default.
- W2082542680 type Work @default.
- W2082542680 sameAs 2082542680 @default.
- W2082542680 citedByCount "31" @default.
- W2082542680 crossrefType "journal-article" @default.
- W2082542680 hasAuthorship W2082542680A5025985212 @default.
- W2082542680 hasAuthorship W2082542680A5026841294 @default.
- W2082542680 hasAuthorship W2082542680A5046567477 @default.
- W2082542680 hasAuthorship W2082542680A5085978683 @default.
- W2082542680 hasBestOaLocation W20825426801 @default.
- W2082542680 hasConcept C121608353 @default.
- W2082542680 hasConcept C126322002 @default.
- W2082542680 hasConcept C126894567 @default.
- W2082542680 hasConcept C141071460 @default.
- W2082542680 hasConcept C2776694085 @default.
- W2082542680 hasConcept C2776755627 @default.
- W2082542680 hasConcept C2777863537 @default.
- W2082542680 hasConcept C2777982462 @default.
- W2082542680 hasConcept C2780192828 @default.
- W2082542680 hasConcept C2780201970 @default.
- W2082542680 hasConcept C2780824555 @default.
- W2082542680 hasConcept C2780849966 @default.
- W2082542680 hasConcept C2994223898 @default.
- W2082542680 hasConcept C71924100 @default.
- W2082542680 hasConceptScore W2082542680C121608353 @default.
- W2082542680 hasConceptScore W2082542680C126322002 @default.
- W2082542680 hasConceptScore W2082542680C126894567 @default.
- W2082542680 hasConceptScore W2082542680C141071460 @default.
- W2082542680 hasConceptScore W2082542680C2776694085 @default.
- W2082542680 hasConceptScore W2082542680C2776755627 @default.
- W2082542680 hasConceptScore W2082542680C2777863537 @default.
- W2082542680 hasConceptScore W2082542680C2777982462 @default.
- W2082542680 hasConceptScore W2082542680C2780192828 @default.
- W2082542680 hasConceptScore W2082542680C2780201970 @default.
- W2082542680 hasConceptScore W2082542680C2780824555 @default.
- W2082542680 hasConceptScore W2082542680C2780849966 @default.
- W2082542680 hasConceptScore W2082542680C2994223898 @default.
- W2082542680 hasConceptScore W2082542680C71924100 @default.
- W2082542680 hasLocation W20825426801 @default.
- W2082542680 hasLocation W20825426802 @default.
- W2082542680 hasOpenAccess W2082542680 @default.
- W2082542680 hasPrimaryLocation W20825426801 @default.
- W2082542680 hasRelatedWork W109349504 @default.
- W2082542680 hasRelatedWork W1969702776 @default.
- W2082542680 hasRelatedWork W1981497922 @default.
- W2082542680 hasRelatedWork W1995511036 @default.
- W2082542680 hasRelatedWork W2084721566 @default.
- W2082542680 hasRelatedWork W2159366134 @default.
- W2082542680 hasRelatedWork W2319341789 @default.
- W2082542680 hasRelatedWork W2953111379 @default.
- W2082542680 hasRelatedWork W2967765818 @default.
- W2082542680 hasRelatedWork W4200544265 @default.
- W2082542680 isParatext "false" @default.
- W2082542680 isRetracted "false" @default.
- W2082542680 magId "2082542680" @default.
- W2082542680 workType "article" @default.