Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082543617> ?p ?o ?g. }
- W2082543617 endingPage "121" @default.
- W2082543617 startingPage "109" @default.
- W2082543617 abstract "Cell adhesion molecules play a major role in determining tissue architecture during histogenesis. This immunocytochemical study of the adrenal gland examines the embryonic and early postnatal cellular expression of two neural cell adhesion molecules, NCAM and L1, which are widely expressed in brain and have been found also to be expressed in the adult rat adrenal gland. In parallel, antibodies directed against two neuroendocrine cell markers, tyrosine hydroxylase and phenylethanolamine N-methyltransferase, were employed to verify the phenotypic nature of developing chromaffin cells in order to correlate cell adhesion molecule expression with the state of chromaffin cell differentiation. NCAM was found to be expressed by chromoblasts within extra-adrenal blastema (i.e. before their migration into the cortical primordium) at the 16th day of embryonic life. It continued to be expressed by all developing chromaffin cells after their infiltration into the developing adrenal gland at all ages. L1 was also expressed by chromoblasts in extra-adrenal sites, but was found only in a subpopulation of chromaffin cells within the cortical primordium from the 16th embryonic day onwards. Those chromoblasts which expressed L1 constituted relatively large compact cell clusters within the gland at this stage, while intra-adrenal chromaffin cells not expressing L1 were dispersed in small cell groups. L1 was also strongly expressed by nerve fibres (and their surrounding Schwann cells) which appeared to innervate cell groups as early as the 16th embryonic day. Both extra- and intra-adrenal chromoblasts expressed tyrosine hydroxylase, but the large L1-positive cell aggregates were less intensely immunoreactive for tyrosine hydroxylase than were cells in small groups. PNMT expression was restricted to L1-negative intra-adrenal chromoblasts present in small groups. Ultrastructural observations demonstrated that cells expressing L1 contained few secretory granules at the 18th embryonic day. It is concluded from these data that these chromoblasts are the precursors of the noradrenergic cells found in the mature gland. In addition, the arrangement of noradrenergic chromaffin cells in the form of homotypic cell groups throughout the course of histogenesis of the adrenal medulla is likely to be a direct consequence of the exclusive co-expression of both NCAM and L1 by this subpopulation of maturing chromaffin cells." @default.
- W2082543617 created "2016-06-24" @default.
- W2082543617 creator A5025490736 @default.
- W2082543617 creator A5035703982 @default.
- W2082543617 creator A5053476939 @default.
- W2082543617 creator A5063247227 @default.
- W2082543617 date "1992-11-01" @default.
- W2082543617 modified "2023-09-25" @default.
- W2082543617 title "Expression of cell adhesion molecules and catecholamine synthesizing enzymes in the developing rat adrenal gland" @default.
- W2082543617 cites W151984366 @default.
- W2082543617 cites W1548796805 @default.
- W2082543617 cites W1554920990 @default.
- W2082543617 cites W1645724162 @default.
- W2082543617 cites W1795682777 @default.
- W2082543617 cites W1848000149 @default.
- W2082543617 cites W1853725381 @default.
- W2082543617 cites W1969267340 @default.
- W2082543617 cites W1972575806 @default.
- W2082543617 cites W1977476498 @default.
- W2082543617 cites W1979019744 @default.
- W2082543617 cites W1984472719 @default.
- W2082543617 cites W1985467463 @default.
- W2082543617 cites W1987506486 @default.
- W2082543617 cites W1994033808 @default.
- W2082543617 cites W1994460947 @default.
- W2082543617 cites W1998489650 @default.
- W2082543617 cites W1999152209 @default.
- W2082543617 cites W2000252657 @default.
- W2082543617 cites W2001014315 @default.
- W2082543617 cites W2002256716 @default.
- W2082543617 cites W2008892611 @default.
- W2082543617 cites W2010488597 @default.
- W2082543617 cites W2011035028 @default.
- W2082543617 cites W2011152374 @default.
- W2082543617 cites W2012447063 @default.
- W2082543617 cites W2012781263 @default.
- W2082543617 cites W2022802110 @default.
- W2082543617 cites W2022854654 @default.
- W2082543617 cites W2024599586 @default.
- W2082543617 cites W2025079340 @default.
- W2082543617 cites W2026852781 @default.
- W2082543617 cites W2029331175 @default.
- W2082543617 cites W2030552215 @default.
- W2082543617 cites W2030716862 @default.
- W2082543617 cites W2037230002 @default.
- W2082543617 cites W2043200416 @default.
- W2082543617 cites W2051750122 @default.
- W2082543617 cites W2053692691 @default.
- W2082543617 cites W2057124171 @default.
- W2082543617 cites W2057472483 @default.
- W2082543617 cites W2058656221 @default.
- W2082543617 cites W2060669189 @default.
- W2082543617 cites W2060826800 @default.
- W2082543617 cites W2061679771 @default.
- W2082543617 cites W2065228349 @default.
- W2082543617 cites W2067082256 @default.
- W2082543617 cites W2072475217 @default.
- W2082543617 cites W2076917151 @default.
- W2082543617 cites W2081879522 @default.
- W2082543617 cites W2088616465 @default.
- W2082543617 cites W2089823302 @default.
- W2082543617 cites W2089896043 @default.
- W2082543617 cites W2090941527 @default.
- W2082543617 cites W2097128116 @default.
- W2082543617 cites W2125253111 @default.
- W2082543617 cites W2132602045 @default.
- W2082543617 cites W2133267068 @default.
- W2082543617 cites W2143265447 @default.
- W2082543617 cites W2166025435 @default.
- W2082543617 cites W2167986100 @default.
- W2082543617 cites W2416205072 @default.
- W2082543617 cites W628632907 @default.
- W2082543617 cites W68792157 @default.
- W2082543617 doi "https://doi.org/10.1016/0165-3806(92)90109-a" @default.
- W2082543617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1361884" @default.
- W2082543617 hasPublicationYear "1992" @default.
- W2082543617 type Work @default.
- W2082543617 sameAs 2082543617 @default.
- W2082543617 citedByCount "16" @default.
- W2082543617 crossrefType "journal-article" @default.
- W2082543617 hasAuthorship W2082543617A5025490736 @default.
- W2082543617 hasAuthorship W2082543617A5035703982 @default.
- W2082543617 hasAuthorship W2082543617A5053476939 @default.
- W2082543617 hasAuthorship W2082543617A5063247227 @default.
- W2082543617 hasConcept C104317684 @default.
- W2082543617 hasConcept C122871604 @default.
- W2082543617 hasConcept C126322002 @default.
- W2082543617 hasConcept C126749454 @default.
- W2082543617 hasConcept C134018914 @default.
- W2082543617 hasConcept C145103041 @default.
- W2082543617 hasConcept C1491633281 @default.
- W2082543617 hasConcept C159167319 @default.
- W2082543617 hasConcept C16224149 @default.
- W2082543617 hasConcept C184750944 @default.
- W2082543617 hasConcept C196843134 @default.
- W2082543617 hasConcept C2775894120 @default.
- W2082543617 hasConcept C2776804559 @default.
- W2082543617 hasConcept C2777597313 @default.