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- W2082551036 abstract "Although the normal human placenta is impermeable to insulin, the effect of anti-insulin antibodies upon the placental barrier to insulin has not been defined. The placental transfer of human insulin-I125 was examined in normal (n=4) and insulin-dependent diabetic mothers (n=4) by infusing human insulin-I125 at a constant rate for 60-90 min. prior to delivery and measuring immuno-precipitable insulin-I125 radioactivity in the maternal and umbilical venous plasma at delivery. In normal mothers plasma insulin-I125 radioactivity was 683±110 cpm/ml (Mean±SEM) in the maternal vein and 6±2 cpm/ml in the umbilical vein. In three diabetic mothers with high plasma insulin binding capacity (1850-8400 μU/ml) the umbilical venous insulin-I125 was 10±10 cpm/ml when the maternal plasma insulin-I125 was maintained at 1388±356 cpm/ml, even though the antibodies were present in the fetal plasma. In another insulin-dependent diabetic mother with negligible anti-insulin antibodies, no placental transfer of human insulin-I125 was demonstrated. Thus, in both normal and diabetic mothers, placental transfer of human insulin-I125 is negligible and the presence of maternal anti-insulin antibodies does not induce insulin transfer." @default.
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- W2082551036 date "1974-04-01" @default.
- W2082551036 modified "2023-09-26" @default.
- W2082551036 title "THE PLACENTAL BARRIER TO HUMAN INSULIN-I-125 IN INSULIN DEPENDENT DIABETIC MOTHERS" @default.
- W2082551036 doi "https://doi.org/10.1203/00006450-197404000-00179" @default.
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