Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082562709> ?p ?o ?g. }
- W2082562709 endingPage "650" @default.
- W2082562709 startingPage "633" @default.
- W2082562709 abstract "Intermediate filaments (IFs) are key players in multiple cellular processes throughout human tissues. Their biochemical and structural properties are important for understanding filament assembly mechanisms, for interactions between IFs and binding partners, and for developing pharmacological agents that target IFs. IF proteins share a conserved coiled-coil central-rod domain flanked by variable N-terminal ‘head’ and C-terminal ‘tail’ domains. There have been several recent advances in our understanding of IF structure from the study of keratins, glial fibrillary acidic protein, and lamin. These include discoveries of (i) a knob–pocket tetramer assembly mechanism in coil 1B; (ii) a lamin-specific coil 1B insert providing a one-half superhelix turn; (iii) helical, yet flexible, linkers within the rod domain; and (iv) the identification of coil 2B residues required for mature filament assembly. Furthermore, the head and tail domains of some IFs contain low-complexity aromatic-rich kinked segments, and structures of IFs with binding partners show electrostatic surfaces are a major contributor to complex formation. These new data advance the connection between IF structure, pathologic mutations, and clinical diseases in humans." @default.
- W2082562709 created "2016-06-24" @default.
- W2082562709 creator A5030501366 @default.
- W2082562709 creator A5090122914 @default.
- W2082562709 date "1996-10-01" @default.
- W2082562709 modified "2023-10-12" @default.
- W2082562709 title "HAIR KERATINIZATION IN HEALTH AND DISEASE" @default.
- W2082562709 cites W1483430311 @default.
- W2082562709 cites W1504857606 @default.
- W2082562709 cites W1969961048 @default.
- W2082562709 cites W1975988029 @default.
- W2082562709 cites W1979040989 @default.
- W2082562709 cites W1985478809 @default.
- W2082562709 cites W1985534974 @default.
- W2082562709 cites W1989109091 @default.
- W2082562709 cites W1991527564 @default.
- W2082562709 cites W1993862280 @default.
- W2082562709 cites W2001773968 @default.
- W2082562709 cites W2003370400 @default.
- W2082562709 cites W2006389168 @default.
- W2082562709 cites W2008605877 @default.
- W2082562709 cites W2016426862 @default.
- W2082562709 cites W2017515632 @default.
- W2082562709 cites W2017609866 @default.
- W2082562709 cites W2025280623 @default.
- W2082562709 cites W2032374483 @default.
- W2082562709 cites W2036881147 @default.
- W2082562709 cites W2037436440 @default.
- W2082562709 cites W2038734979 @default.
- W2082562709 cites W2040187986 @default.
- W2082562709 cites W2041460044 @default.
- W2082562709 cites W2043706627 @default.
- W2082562709 cites W2043756580 @default.
- W2082562709 cites W2044453539 @default.
- W2082562709 cites W2052522043 @default.
- W2082562709 cites W2058898209 @default.
- W2082562709 cites W2059140878 @default.
- W2082562709 cites W2062836206 @default.
- W2082562709 cites W2069190004 @default.
- W2082562709 cites W2069860300 @default.
- W2082562709 cites W2070337310 @default.
- W2082562709 cites W2071775216 @default.
- W2082562709 cites W2072024103 @default.
- W2082562709 cites W2072882134 @default.
- W2082562709 cites W2074790526 @default.
- W2082562709 cites W2076537660 @default.
- W2082562709 cites W2079170988 @default.
- W2082562709 cites W2080377992 @default.
- W2082562709 cites W2080434495 @default.
- W2082562709 cites W2081515513 @default.
- W2082562709 cites W2089598949 @default.
- W2082562709 cites W2089952622 @default.
- W2082562709 cites W2090912648 @default.
- W2082562709 cites W2091556699 @default.
- W2082562709 cites W2093625965 @default.
- W2082562709 cites W2097060373 @default.
- W2082562709 cites W2102753325 @default.
- W2082562709 cites W2110516509 @default.
- W2082562709 cites W2110864649 @default.
- W2082562709 cites W2122412289 @default.
- W2082562709 cites W2125911728 @default.
- W2082562709 cites W2127416049 @default.
- W2082562709 cites W2127841064 @default.
- W2082562709 cites W2127844687 @default.
- W2082562709 cites W2129471415 @default.
- W2082562709 cites W2140442862 @default.
- W2082562709 cites W2144120738 @default.
- W2082562709 cites W2149827167 @default.
- W2082562709 cites W2156339356 @default.
- W2082562709 cites W2156989901 @default.
- W2082562709 cites W2414596506 @default.
- W2082562709 cites W248609722 @default.
- W2082562709 cites W2526005983 @default.
- W2082562709 doi "https://doi.org/10.1016/s0733-8635(05)70390-9" @default.
- W2082562709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9238322" @default.
- W2082562709 hasPublicationYear "1996" @default.
- W2082562709 type Work @default.
- W2082562709 sameAs 2082562709 @default.
- W2082562709 citedByCount "22" @default.
- W2082562709 countsByYear W20825627092014 @default.
- W2082562709 countsByYear W20825627092019 @default.
- W2082562709 countsByYear W20825627092020 @default.
- W2082562709 countsByYear W20825627092021 @default.
- W2082562709 crossrefType "journal-article" @default.
- W2082562709 hasAuthorship W2082562709A5030501366 @default.
- W2082562709 hasAuthorship W2082562709A5090122914 @default.
- W2082562709 hasConcept C104317684 @default.
- W2082562709 hasConcept C122146531 @default.
- W2082562709 hasConcept C12554922 @default.
- W2082562709 hasConcept C14228908 @default.
- W2082562709 hasConcept C142669718 @default.
- W2082562709 hasConcept C1491633281 @default.
- W2082562709 hasConcept C158456008 @default.
- W2082562709 hasConcept C167625842 @default.
- W2082562709 hasConcept C179093185 @default.
- W2082562709 hasConcept C181199279 @default.
- W2082562709 hasConcept C2778886173 @default.
- W2082562709 hasConcept C2779408652 @default.