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• W2082572010 abstract "Radiotracer kinetic modeling in small animals with Positron Emission Tomography (PET) requires the determination of the blood tracer concentration as a function of time. A continuous blood counting system was designed to measure the input function from rats and mice in real time. The system consists of a flow-through beta counter made of silicon PIN photodiodes and a mul syringe pump. The latter draws blood continuously from an implanted venous or arterial catheter, at a user selected rate. The direct beta detection by photodiodes minimizes the shield footprint next to the animal and reduces the counter sensitivity to ambient gamma radiation. The device is entirely remote controlled for sampling protocol selection, tuning, and real time monitoring of measured parameters. It can be hooked to a computer or fully integrated with the LabPETtrade scanner for blood counting during dynamic PET imaging experiments. The counter sensitivity to the most popular PET radioisotopes ( <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F, <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>64</sup> Cu, <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>13</sup> N, <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>11 </sup> C) ranges from 7.1 to 46.8 Bq/mul. Its linearity is better than 98% up to 46 kBq/mul for <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F, and a 1.4 s dispersion constant was measured at a rate of 250 mul/min with rat whole blood in a PE10 catheter. Due to its optimized mechanical design and compact shielding, the counter sensitivity to radioactive background is only 5 counts per second (cps) for a 37 MBq <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F source 10 cm away from the detector. Accurate time-activity curves have been obtained from rats and mice in dynamic PET imaging studies" @default.
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• W2082572010 date "2007-02-01" @default.
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• W2082572010 title "A Microvolumetric $beta$ Blood Counter for Pharmacokinetic PET Studies in Small Animals" @default.
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• W2082572010 doi "https://doi.org/10.1109/tns.2006.889166" @default.
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