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• W2082579551 abstract "Surgery is currently the only curative treatment for patients with cholangiocarcinoma (CCA). Whether histological diagnosis of CCA is necessary before surgery is controversial. Fifteen percent of patients with suspected biliary malignancy who undergo surgery are found to have benign disease. Surgery is a major procedure with significant morbidity and mortality and alternative treatment is available for those known to have benign stenoses. The aim of this review was to determine whether any of the current diagnostic tests have sufficient sensitivity and specificity to identify patients with benign and malignant bile duct stenoses. A literature search was performed until July 2007 to obtain information from studies published in the previous 10 years. Only studies reporting an appropriate reference test (confirmation of malignancy by biopsy, confirmation of benign nature by histology following surgical excision, or at least 6 months of follow-up for all patients) were included for review. The diagnostic odds ratio was used to measure diagnostic performance. Forty-one references of 34 studies were included in this review. None of the studies used differential verification. Six studies used blinding of assessor. None of the diagnostic tests had sufficient diagnostic accuracy to reliably separate patients with benign from malignant biliary strictures. Differentiating benign from malignant bile strictures is an important aim. There is no trial evidence demonstrating benefit in obtaining a preoperative histological diagnosis of CCA. New methods are required for stricture assessment." @default.
• W2082579551 created "2016-06-24" @default.
• W2082579551 creator A5045604232 @default.
• W2082579551 creator A5079079428 @default.
• W2082579551 date "2008-04-01" @default.
• W2082579551 modified "2023-10-04" @default.
• W2082579551 title "Is preoperative histological diagnosis necessary for cholangiocarcinoma?" @default.
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• W2082579551 doi "https://doi.org/10.1080/13651820801992633" @default.
• W2082579551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2504384" @default.
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• W2082579551 hasPublicationYear "2008" @default.
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