FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082607972> ?p ?o ?g. }

• W2082607972 endingPage "341" @default.
• W2082607972 startingPage "334" @default.
• W2082607972 abstract "Increased amounts of bilirubin, the end product of heme degradation, are known to be detrimental to the central nervous system, especially in preterm newborns. In an attempt to delineate the cellular mechanisms by which unconjugated bilirubin exerts its toxic effects on neuronal cells in the developing brain, bilirubin (0.25-5 microM) was added to the extracellular medium of 6-day-old primary cultured neurons from the embryonic rat forebrain, and cell alterations were studied over the ensuing 96 h. Bilirubin decreased cell viability dose dependently with an ED(50) around 1 microM. At the dose of 0.5 microM, it triggered delayed cell death that affected 24% of the neurons. Nuclear incorporation of the fluorescent dye DAPI (4,6-diamidino-2-phenylindole) depicted the presence of apoptosis (16%). Apoptosis features were confirmed by DNA fragmentation reflected by a progressive loss of [(3)H]thymidine and sequential changes in macromolecular synthesis, as shown by the time course of [(3)H]leucine incorporation, as well as by the beneficial effects of cycloheximide and caspase inhibitors. In parallel, treatments with glutamate receptor antagonists showed that MK-801, but not NBQX, protected neurons against bilirubin neurotoxicity, suggesting a role for NMDA receptors in bilirubin effects. Coupled with previous work about glutamate toxicity in the same culture model, these data support the hypothesis that low levels of free bilirubin may promote programmed neuronal death corresponding to an apoptotic process which involves caspase activation and requires the participation of NMDA receptors, along with bilirubin-induced inhibition of protein kinase C activity." @default.
• W2082607972 created "2016-06-24" @default.
• W2082607972 creator A5000273598 @default.
• W2082607972 creator A5068610992 @default.
• W2082607972 creator A5070569716 @default.
• W2082607972 creator A5078573429 @default.
• W2082607972 date "2000-12-01" @default.
• W2082607972 modified "2023-09-24" @default.
• W2082607972 title "Bilirubin Induces Apoptosis via Activation of NMDA Receptors in Developing Rat Brain Neurons" @default.
• W2082607972 cites W1522366213 @default.
• W2082607972 cites W1582647980 @default.
• W2082607972 cites W1888982058 @default.
• W2082607972 cites W1919287714 @default.
• W2082607972 cites W1928260425 @default.
• W2082607972 cites W1942214720 @default.
• W2082607972 cites W19536726 @default.
• W2082607972 cites W1966434770 @default.
• W2082607972 cites W1966513873 @default.
• W2082607972 cites W1966569555 @default.
• W2082607972 cites W1968249160 @default.
• W2082607972 cites W1969796465 @default.
• W2082607972 cites W1970053452 @default.
• W2082607972 cites W1971335269 @default.
• W2082607972 cites W1973068720 @default.
• W2082607972 cites W1973567298 @default.
• W2082607972 cites W1973846776 @default.
• W2082607972 cites W1977487469 @default.
• W2082607972 cites W1982444570 @default.
• W2082607972 cites W1990917512 @default.
• W2082607972 cites W2004754982 @default.
• W2082607972 cites W2009512214 @default.
• W2082607972 cites W2014773550 @default.
• W2082607972 cites W2016342220 @default.
• W2082607972 cites W2018125558 @default.
• W2082607972 cites W2022690437 @default.
• W2082607972 cites W2023634255 @default.
• W2082607972 cites W2036685561 @default.
• W2082607972 cites W2044230606 @default.
• W2082607972 cites W2049722732 @default.
• W2082607972 cites W2050365720 @default.
• W2082607972 cites W2050746675 @default.
• W2082607972 cites W2051214207 @default.
• W2082607972 cites W2051344987 @default.
• W2082607972 cites W2054526986 @default.
• W2082607972 cites W2056077442 @default.
• W2082607972 cites W2059301083 @default.
• W2082607972 cites W2061758925 @default.
• W2082607972 cites W2070556319 @default.
• W2082607972 cites W2070964315 @default.
• W2082607972 cites W2072803092 @default.
• W2082607972 cites W2089717156 @default.
• W2082607972 cites W2095163420 @default.
• W2082607972 cites W2097119300 @default.
• W2082607972 cites W2097293665 @default.
• W2082607972 cites W2147039383 @default.
• W2082607972 cites W2415578163 @default.
• W2082607972 cites W2499560088 @default.
• W2082607972 cites W4293247451 @default.
• W2082607972 cites W2003807286 @default.
• W2082607972 doi "https://doi.org/10.1006/exnr.2000.7518" @default.
• W2082607972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11085898" @default.
• W2082607972 hasPublicationYear "2000" @default.
• W2082607972 type Work @default.
• W2082607972 sameAs 2082607972 @default.
• W2082607972 citedByCount "127" @default.
• W2082607972 countsByYear W20826079722012 @default.
• W2082607972 countsByYear W20826079722013 @default.
• W2082607972 countsByYear W20826079722014 @default.
• W2082607972 countsByYear W20826079722015 @default.
• W2082607972 countsByYear W20826079722016 @default.
• W2082607972 countsByYear W20826079722017 @default.
• W2082607972 countsByYear W20826079722018 @default.
• W2082607972 countsByYear W20826079722019 @default.
• W2082607972 countsByYear W20826079722020 @default.
• W2082607972 countsByYear W20826079722021 @default.
• W2082607972 countsByYear W20826079722022 @default.
• W2082607972 countsByYear W20826079722023 @default.
• W2082607972 crossrefType "journal-article" @default.
• W2082607972 hasAuthorship W2082607972A5000273598 @default.
• W2082607972 hasAuthorship W2082607972A5068610992 @default.
• W2082607972 hasAuthorship W2082607972A5070569716 @default.
• W2082607972 hasAuthorship W2082607972A5078573429 @default.
• W2082607972 hasConcept C126322002 @default.
• W2082607972 hasConcept C134018914 @default.
• W2082607972 hasConcept C169760540 @default.
• W2082607972 hasConcept C170493617 @default.
• W2082607972 hasConcept C190283241 @default.
• W2082607972 hasConcept C2777513400 @default.
• W2082607972 hasConcept C2777527632 @default.
• W2082607972 hasConcept C2778128677 @default.
• W2082607972 hasConcept C2778794669 @default.
• W2082607972 hasConcept C2779491297 @default.
• W2082607972 hasConcept C29730261 @default.
• W2082607972 hasConcept C31573885 @default.
• W2082607972 hasConcept C3675279 @default.
• W2082607972 hasConcept C43759708 @default.
• W2082607972 hasConcept C55493867 @default.
• W2082607972 hasConcept C61174792 @default.

• next