FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082616204> ?p ?o ?g. }

• W2082616204 endingPage "379" @default.
• W2082616204 startingPage "372" @default.
• W2082616204 abstract "Epidermal keratinocytes undergo differentiation in response to several stimuli to form the cornified envelope, a structure that contributes to the barrier function of skin. Although differentiation has been extensively analyzed, the precise role of vitamin C during this process is still not defined. Ascorbic acid, besides acting as a radical scavenger, has been shown to promote mesenchymal differentiation. In this study, we found that keratinocytes grown in ascorbate-supplemented medium developed a differentiated phenotype, as demonstrated by enhanced expression of marker genes and increase in cornified envelope content. The pro-differentiating effects of ascorbate were mediated by the protein-kinase-C-dependent induction of activating protein 1 DNA binding activity; indeed, down-modulation of protein kinase C activity abolished differentiation triggered by ascorbic acid. Although vitamin C appeared to regulate the same signaling pathway modulated by calcium, a classical in vitro inducer of epidermal differentiation, nonetheless terminally differentiated keratinocytes exhibited different ascorbate homeostasis and cellular antioxidant status. Indeed, we found that, unlike calcium, differentiation promoted by ascorbate was accompanied by (i) an enhanced ascorbate transport, due to overexpression of specific transporters, (ii) a great efficiency of dehydroascorbate uptake, and (iii) an increase in glutathione content with respect to proliferating cells. Ascorbic acid may be useful to promote epidermal differentiation, avoiding depletion of hydrophilic antioxidant stores." @default.
• W2082616204 created "2016-06-24" @default.
• W2082616204 creator A5002844341 @default.
• W2082616204 creator A5003335216 @default.
• W2082616204 creator A5043072893 @default.
• W2082616204 creator A5058936664 @default.
• W2082616204 creator A5063616237 @default.
• W2082616204 creator A5074237946 @default.
• W2082616204 date "2002-02-01" @default.
• W2082616204 modified "2023-09-30" @default.
• W2082616204 title "Characterization of Keratinocyte Differentiation Induced by Ascorbic Acid: Protein Kinase C Involvement and Vitamin C Homeostasis11The authors declared not to have a conflict of interest." @default.
• W2082616204 cites W1517698775 @default.
• W2082616204 cites W1540529899 @default.
• W2082616204 cites W1577204939 @default.
• W2082616204 cites W1593187788 @default.
• W2082616204 cites W1601650782 @default.
• W2082616204 cites W1657916452 @default.
• W2082616204 cites W1755902553 @default.
• W2082616204 cites W1882211948 @default.
• W2082616204 cites W1972549014 @default.
• W2082616204 cites W1978962336 @default.
• W2082616204 cites W1995825628 @default.
• W2082616204 cites W2001403326 @default.
• W2082616204 cites W2005413052 @default.
• W2082616204 cites W2016730049 @default.
• W2082616204 cites W2018613236 @default.
• W2082616204 cites W2021861995 @default.
• W2082616204 cites W2023666553 @default.
• W2082616204 cites W2030068752 @default.
• W2082616204 cites W2030709480 @default.
• W2082616204 cites W2036224418 @default.
• W2082616204 cites W2038085058 @default.
• W2082616204 cites W2040842912 @default.
• W2082616204 cites W2047278386 @default.
• W2082616204 cites W2055061387 @default.
• W2082616204 cites W2065020384 @default.
• W2082616204 cites W2066028044 @default.
• W2082616204 cites W2071262907 @default.
• W2082616204 cites W2076229947 @default.
• W2082616204 cites W2078523226 @default.
• W2082616204 cites W2091673674 @default.
• W2082616204 cites W2102455595 @default.
• W2082616204 cites W2114291663 @default.
• W2082616204 cites W2143464311 @default.
• W2082616204 cites W2145575133 @default.
• W2082616204 cites W2179648658 @default.
• W2082616204 cites W2994158156 @default.
• W2082616204 cites W4248942107 @default.
• W2082616204 cites W4293247451 @default.
• W2082616204 cites W758260955 @default.
• W2082616204 doi "https://doi.org/10.1046/j.0022-202x.2001.01624.x" @default.
• W2082616204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11841559" @default.
• W2082616204 hasPublicationYear "2002" @default.
• W2082616204 type Work @default.
• W2082616204 sameAs 2082616204 @default.
• W2082616204 citedByCount "79" @default.
• W2082616204 countsByYear W20826162042013 @default.
• W2082616204 countsByYear W20826162042014 @default.
• W2082616204 countsByYear W20826162042015 @default.
• W2082616204 countsByYear W20826162042016 @default.
• W2082616204 countsByYear W20826162042017 @default.
• W2082616204 countsByYear W20826162042018 @default.
• W2082616204 countsByYear W20826162042019 @default.
• W2082616204 countsByYear W20826162042020 @default.
• W2082616204 countsByYear W20826162042021 @default.
• W2082616204 countsByYear W20826162042022 @default.
• W2082616204 countsByYear W20826162042023 @default.
• W2082616204 crossrefType "journal-article" @default.
• W2082616204 hasAuthorship W2082616204A5002844341 @default.
• W2082616204 hasAuthorship W2082616204A5003335216 @default.
• W2082616204 hasAuthorship W2082616204A5043072893 @default.
• W2082616204 hasAuthorship W2082616204A5058936664 @default.
• W2082616204 hasAuthorship W2082616204A5063616237 @default.
• W2082616204 hasAuthorship W2082616204A5074237946 @default.
• W2082616204 hasBestOaLocation W20826162041 @default.
• W2082616204 hasConcept C104317684 @default.
• W2082616204 hasConcept C148738053 @default.
• W2082616204 hasConcept C184235292 @default.
• W2082616204 hasConcept C185592680 @default.
• W2082616204 hasConcept C202751555 @default.
• W2082616204 hasConcept C2777074287 @default.
• W2082616204 hasConcept C2778004101 @default.
• W2082616204 hasConcept C2780022331 @default.
• W2082616204 hasConcept C2986274086 @default.
• W2082616204 hasConcept C31903555 @default.
• W2082616204 hasConcept C55493867 @default.
• W2082616204 hasConcept C86803240 @default.
• W2082616204 hasConcept C95444343 @default.
• W2082616204 hasConcept C97029542 @default.
• W2082616204 hasConceptScore W2082616204C104317684 @default.
• W2082616204 hasConceptScore W2082616204C148738053 @default.
• W2082616204 hasConceptScore W2082616204C184235292 @default.
• W2082616204 hasConceptScore W2082616204C185592680 @default.
• W2082616204 hasConceptScore W2082616204C202751555 @default.
• W2082616204 hasConceptScore W2082616204C2777074287 @default.
• W2082616204 hasConceptScore W2082616204C2778004101 @default.
• W2082616204 hasConceptScore W2082616204C2780022331 @default.
• W2082616204 hasConceptScore W2082616204C2986274086 @default.

• next