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• W2082635893 abstract "OBJECTIVE: To develop criteria for selection of patients who are good candidates for single embryo transfer.DESIGN: Prospective evaluation of young patients with good embryo development in a large private practice.MATERIALS AND METHODS: All patients were treated with an oral contraceptive/leuprolide acetate down regulation protocol. Recombinant FSH alone was used for ovarian stimulation. All patients received recombinant hCG at oocyte maturity, followed by transvaginal oocyte retrieval 36 hours later. Progesterone suplementation was begun 2 days after oocyte retrieval. Embryos were transferred 5 days following retrieval. Patients were offered the opportunity to transfer only one embryo if they met the following criteria: <35 years of age, no previous unsuccessful IVF cycles, and having at least one embryo that met criteria for cryopreservation on the day of embryo transfer. Patients who did not choose to transfer one embryo underwent transfer of two embryos. A serum hCG was obtained 14 days after retrieval and weekly if positive until transvaginal sonography was performed at 7 weeks' gestational age.RESULTS: 26 patients chose to undergo a single embryo transfer; 18 (69%) of these had a clinical pregnancy. 186 patients chose to transfer 2 embryos; 145 (78%) had a clinical pregnancy. The pregnancy rate for the group that chose to transfer two embryos was not statistically different (chi square analysis, p=0.46) from those that chose to transfer one embryo. However, the multiple pregnancy rate was higher for the group that chose to transfer 2 embryos (52% vs. 0) and that group included five sets of triplets.CONCLUSION: Young women undergoing IVF with embryo development sufficient to have at least one other embryo available for cryopreservation had an excellent chance of pregnancy when only one embryo was transferred and should therefore be offered a single embryo transfer. Transferring 2 embryos in this group increased the risk of multiples without significantly increasing the chance for pregnancy. OBJECTIVE: To develop criteria for selection of patients who are good candidates for single embryo transfer. DESIGN: Prospective evaluation of young patients with good embryo development in a large private practice. MATERIALS AND METHODS: All patients were treated with an oral contraceptive/leuprolide acetate down regulation protocol. Recombinant FSH alone was used for ovarian stimulation. All patients received recombinant hCG at oocyte maturity, followed by transvaginal oocyte retrieval 36 hours later. Progesterone suplementation was begun 2 days after oocyte retrieval. Embryos were transferred 5 days following retrieval. Patients were offered the opportunity to transfer only one embryo if they met the following criteria: <35 years of age, no previous unsuccessful IVF cycles, and having at least one embryo that met criteria for cryopreservation on the day of embryo transfer. Patients who did not choose to transfer one embryo underwent transfer of two embryos. A serum hCG was obtained 14 days after retrieval and weekly if positive until transvaginal sonography was performed at 7 weeks' gestational age. RESULTS: 26 patients chose to undergo a single embryo transfer; 18 (69%) of these had a clinical pregnancy. 186 patients chose to transfer 2 embryos; 145 (78%) had a clinical pregnancy. The pregnancy rate for the group that chose to transfer two embryos was not statistically different (chi square analysis, p=0.46) from those that chose to transfer one embryo. However, the multiple pregnancy rate was higher for the group that chose to transfer 2 embryos (52% vs. 0) and that group included five sets of triplets. CONCLUSION: Young women undergoing IVF with embryo development sufficient to have at least one other embryo available for cryopreservation had an excellent chance of pregnancy when only one embryo was transferred and should therefore be offered a single embryo transfer. Transferring 2 embryos in this group increased the risk of multiples without significantly increasing the chance for pregnancy." @default.
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• W2082635893 date "2010-09-01" @default.
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• W2082635893 title "Selection of young patients using strict criteria allows an excellent chance of pregnancy when transferring a single emebryo while avoiding a high risk of multple gestation" @default.
• W2082635893 doi "https://doi.org/10.1016/j.fertnstert.2010.07.092" @default.
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