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• W2082641909 endingPage "816" @default.
• W2082641909 startingPage "809" @default.
• W2082641909 abstract "The intratracheal instillation of recombinant human interleukin-5 (rhIL-5) into isolated lungs from sensitized and antigen-boosted guinea pigs is followed by enhanced responses to platelet-activating factor (PAF).Modulation by nedocromil sodium of rhIL-5-dependent hyperresponsiveness to PAF was investigated. Perfused lungs from guinea pigs actively sensitized to ovalbumin were injected intratracheally with 300 ng rhIL-5 followed by PAF (10 and 100 ng intraarterially).No inhibition of rhIL-5-induced increased bronchoconstriction and release of thromboxane (TX)B2 and histamine by PAF was observed when nedocromil sodium (10 mumol/L) was perfused into the lungs. In contrast, when guinea pigs were treated for 2 days (30 mg/kg twice a day), eosinophil recruitment into the bronchoalveolar lavage fluid and hyperresponsiveness to PAF were markedly reduced (100% [p < 0.001]; around 70% [p < 0.05] and around 90% [p < 0.001] inhibition for bronchoconstriction, TXB2 and histamine release, respectively).Our results indicate that nedocromil sodium prevents the rhIL-5-induced lung hyperresponsiveness to PAF and the eosinophil migration into the airways only when it is administered in vivo. It is thus suggested that nedocromil sodium interferes with the development of airway inflammation by inhibiting the recruitment in the lung of a target on which PAF and IL-5 interact." @default.
• W2082641909 created "2016-06-24" @default.
• W2082641909 creator A5021630549 @default.
• W2082641909 creator A5076900431 @default.
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• W2082641909 date "1993-03-01" @default.
• W2082641909 modified "2023-09-24" @default.
• W2082641909 title "Inhibition by nedocromil sodium of recombinant human interieukin-5-induced lung hyperresponsiveness to platelet-activating factor in actively sensitized guinea pigs" @default.
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• W2082641909 doi "https://doi.org/10.1016/0091-6749(93)90201-p" @default.
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• W2082641909 hasPublicationYear "1993" @default.
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