Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082652816> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2082652816 endingPage "1055" @default.
- W2082652816 startingPage "1050" @default.
- W2082652816 abstract "Previous studies have shown that nitroglycerin (TNG) exerts beneficial electrophysiological effects in the setting of acute myocardial ischemia. To investigate the basis for these actions, the effects of TNG during coronary occlusion were studied in 19 anesthetized mongrel dogs. Refractory periods (obtained by extrastimulus method) and conduction times measured from local electrograms were determined in potentially ischemic and nonischemic areas prior to and after varying periods of occlusion of the left anterior descending coronary artery and following administration of TNG (300-400 mug intravenous bolus followed by an infusion titrated to reduce systolic blood pressure by 20 mm Hg). Following 15 minutes of occlusion, refractory periods in the ischemic zones shortened to 83% of control (P less than 0.001) resulting in a difference between refractory periods in the nonischemic and ischemic zones of 17.7%. After TNG administration this difference was decreased to 10.0% (P less than 0.001). However, with periods of occlusion of 60-90 min TNG did not significantly affect the difference of refractory periods. TNG had no significant effects on conduction times in nonischemic or ischemic areas. In six dogs, the effects of coronary occlusion and TNG on ventricular automaticity were examined by induction of complete heart block. The idioventricular rate and ventricular escape intervals after cessation of ventricular overdrive were used as indices of automaticity. Control idioventricular rates (62.5 +/- 3.7 beats/min) remained unchanged following both coronary occlusion (62.0 +/- 3.9) and TNG administration (60.7 +/- 3.2). Similarly, mean control escape intervals (1.84 +/- 0.2 sec) did not change after occlusion (1.78 +/- 0.3 sec) or TNG administration (1.86 +/- 0.2 sec). In conclusion, these observations suggest that 1) TNG enhances the electrical stability of the acutely ischemic myocardium by decreasing the difference of refractory periods between nonischemic and ischemic areas in the immediate period following occlusion, 2) since TNG has no significant effects on ventricular automaticity, its beneficial effects might be limited in suppression of arrhythmias of re-entrant origin." @default.
- W2082652816 created "2016-06-24" @default.
- W2082652816 creator A5024978360 @default.
- W2082652816 creator A5049506795 @default.
- W2082652816 creator A5086191966 @default.
- W2082652816 date "1975-12-01" @default.
- W2082652816 modified "2023-09-25" @default.
- W2082652816 title "Electrophysiologic effects of nitroglycerin during experimental coronary occlusion." @default.
- W2082652816 cites W2020102115 @default.
- W2082652816 doi "https://doi.org/10.1161/01.cir.52.6.1050" @default.
- W2082652816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/810264" @default.
- W2082652816 hasPublicationYear "1975" @default.
- W2082652816 type Work @default.
- W2082652816 sameAs 2082652816 @default.
- W2082652816 citedByCount "28" @default.
- W2082652816 countsByYear W20826528162016 @default.
- W2082652816 countsByYear W20826528162017 @default.
- W2082652816 crossrefType "journal-article" @default.
- W2082652816 hasAuthorship W2082652816A5024978360 @default.
- W2082652816 hasAuthorship W2082652816A5049506795 @default.
- W2082652816 hasAuthorship W2082652816A5086191966 @default.
- W2082652816 hasBestOaLocation W20826528161 @default.
- W2082652816 hasConcept C126322002 @default.
- W2082652816 hasConcept C164705383 @default.
- W2082652816 hasConcept C2776268601 @default.
- W2082652816 hasConcept C2777953023 @default.
- W2082652816 hasConcept C2780393670 @default.
- W2082652816 hasConcept C2780451601 @default.
- W2082652816 hasConcept C42219234 @default.
- W2082652816 hasConcept C43376680 @default.
- W2082652816 hasConcept C541997718 @default.
- W2082652816 hasConcept C70616116 @default.
- W2082652816 hasConcept C71924100 @default.
- W2082652816 hasConcept C84393581 @default.
- W2082652816 hasConceptScore W2082652816C126322002 @default.
- W2082652816 hasConceptScore W2082652816C164705383 @default.
- W2082652816 hasConceptScore W2082652816C2776268601 @default.
- W2082652816 hasConceptScore W2082652816C2777953023 @default.
- W2082652816 hasConceptScore W2082652816C2780393670 @default.
- W2082652816 hasConceptScore W2082652816C2780451601 @default.
- W2082652816 hasConceptScore W2082652816C42219234 @default.
- W2082652816 hasConceptScore W2082652816C43376680 @default.
- W2082652816 hasConceptScore W2082652816C541997718 @default.
- W2082652816 hasConceptScore W2082652816C70616116 @default.
- W2082652816 hasConceptScore W2082652816C71924100 @default.
- W2082652816 hasConceptScore W2082652816C84393581 @default.
- W2082652816 hasIssue "6" @default.
- W2082652816 hasLocation W20826528161 @default.
- W2082652816 hasLocation W20826528162 @default.
- W2082652816 hasOpenAccess W2082652816 @default.
- W2082652816 hasPrimaryLocation W20826528161 @default.
- W2082652816 hasRelatedWork W1990657636 @default.
- W2082652816 hasRelatedWork W2022352750 @default.
- W2082652816 hasRelatedWork W2038661164 @default.
- W2082652816 hasRelatedWork W2061684723 @default.
- W2082652816 hasRelatedWork W2082652816 @default.
- W2082652816 hasRelatedWork W2089264497 @default.
- W2082652816 hasRelatedWork W2195513968 @default.
- W2082652816 hasRelatedWork W2383375557 @default.
- W2082652816 hasRelatedWork W2392801217 @default.
- W2082652816 hasRelatedWork W3152342527 @default.
- W2082652816 hasVolume "52" @default.
- W2082652816 isParatext "false" @default.
- W2082652816 isRetracted "false" @default.
- W2082652816 magId "2082652816" @default.
- W2082652816 workType "article" @default.