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- W2082657156 abstract "To explore the role of the 10-kDa Mycobacterium tuberculosis-specific secreted antigen (MTSA-10 or CFP-10) in modulation of macrophage function, J774 macrophages were transfected stably with DNA encoding MTSA-10. Compared to normal or mock-transfected controls, MTSA-10-expressing macrophages had markedly lower levels of co-stimulatory molecule B7.1 on their surface, while the expression of B7.2 and ICAM-1 was not affected. MTSA-transfected cells also produced significantly less microbicidal free radical nitric oxide (NO) upon stimulation with interferon (IFN)-gamma, lipopolysaccharide or M. tuberculosis cell lysate. Western blot analysis revealed the absence of tyrosine-phosphorylated protein slightly larger than 112 kDa in MTSA-transfected macrophages. Moreover, the treatment of control J774 cells with protein tyrosine kinase inhibitor genistein completely mimicked the effects of transfection with MTSA-10, selectively down-regulating NO and B7.1, but not B7.2 or ICAM-1 expression. The observed MTSA-10-mediated block of B7.1 expression and NO release might contribute to the suppression of antimycobacterial response in tuberculosis." @default.
- W2082657156 created "2016-06-24" @default.
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- W2082657156 date "2003-09-03" @default.
- W2082657156 modified "2023-10-14" @default.
- W2082657156 title "Intracellular expression of<i>Mycobacterium tuberculosis</i>-specific 10-kDa antigen down-regulates macrophage B7·1 expression and nitric oxide release" @default.
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- W2082657156 doi "https://doi.org/10.1046/j.1365-2249.2003.02258.x" @default.
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