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• W2082695400 abstract "p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we show that cisplatin and UV radiation induce G2/M arrest which is temporally linked to p53-protein induction. To study the contribution of p53 to this G2/M arrest, we inhibited p53 induction in NHFs using p53 anti-sense oligonucleotides. Following exposure of NHFs to UV radiation, the inhibition of p53-protein induction leads to a greater accumulation of cells in the G2/M phase, but also to a decreased fraction of cells in the G1 phase. We propose that p53 does not induce G2/M arrest directly, and that the extent of this arrest may depend on the fraction of cells that do not stop at the G1 phase following exposure to DNA-damaging agents. Furthermore, inhibition of p53-protein induction leads to increased sensitivity of NHFs to UV radiation. These results suggest that inhibition of p53 protein enhances sensitivity to DNA-damaging agents in normal human cells. Int. J. Cancer 75:432–438, 1998. © 1998 Wiley-Liss, Inc." @default.
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• W2082695400 date "1998-01-30" @default.
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• W2082695400 title "Inactivation of p53 in normal human cells increases G2/M arrest and sensitivity to DNA-damaging agents" @default.
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• W2082695400 doi "https://doi.org/10.1002/(sici)1097-0215(19980130)75:3<432::aid-ijc17>3.0.co;2-a" @default.
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