Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082703233> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2082703233 endingPage "167" @default.
- W2082703233 startingPage "156" @default.
- W2082703233 abstract "The purpose of the study is to investigate dissolution behaviour of norfloxacin as a model hydrophobic drug through application of liquisolid technology. Norfloxacin was prepared as liquisolid formulations using either flowability or compressibility liquisolid tests. The dissolution profiles were evaluated and compared to counterpart conventional norfloxacin tablets. Two non-volatile liquid vehicles were used in the preparation of norfloxacin liquisolid formulations; Poly Ethylene Glycol (PEG200) and Synperonic PE/L-61. The liquisolid formulations of norfloxacin were tested according to the specification of British Pharmacopoeia (BP) quality control tests. Moreover, the pre-preparation evaluation tests, such as powder flowability Carr index, differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR), were applied for further investigation of the physicochemical properties of the liquisolid formulations. The results indicated that the percentage of norfloxacin release in acetate buffer solution (pH = 4.0) is higher than in distilled water. Also, at the first 20 min, the percentage of the drug release is higher only in the decreased amount of liquid vehicle formulations compared with the conventional tablet. Generally, the conventional tablet dissolution profile is either similar or higher than liquisolid tablets. Moreover, Synperonic PE/L-61 liquisolid tablets showed higher dissolution profiles than PEG200 liquisolid tablets, although the solubility of norfloxacin in PEG200 (2.507 mg/ml) is much higher than in Synperonic PE/L-61 (0.167 mg/ml). In conclusion, increasing the percentage of liquid vehicle in the prepared norfloxacin liquisolid formulations does not necessarily lead to increase in the percentage of the drug release in distilled water dissolution medium." @default.
- W2082703233 created "2016-06-24" @default.
- W2082703233 creator A5056884838 @default.
- W2082703233 creator A5058559078 @default.
- W2082703233 creator A5071011347 @default.
- W2082703233 date "2014-05-01" @default.
- W2082703233 modified "2023-10-18" @default.
- W2082703233 title "Norfloxacin as a model hydrophobic drug with unique release from liquisolid formulations prepared with PEG200 and Synperonic PE/L-61 non-volatile liquid vehicles" @default.
- W2082703233 cites W1488231669 @default.
- W2082703233 cites W1499317429 @default.
- W2082703233 cites W1977592799 @default.
- W2082703233 cites W1980535921 @default.
- W2082703233 cites W1999783151 @default.
- W2082703233 cites W2011882003 @default.
- W2082703233 cites W2013852604 @default.
- W2082703233 cites W2031553055 @default.
- W2082703233 cites W2061112899 @default.
- W2082703233 cites W2064615374 @default.
- W2082703233 cites W2071317778 @default.
- W2082703233 cites W2072185489 @default.
- W2082703233 cites W2077574082 @default.
- W2082703233 cites W2086130473 @default.
- W2082703233 doi "https://doi.org/10.1016/j.powtec.2014.02.048" @default.
- W2082703233 hasPublicationYear "2014" @default.
- W2082703233 type Work @default.
- W2082703233 sameAs 2082703233 @default.
- W2082703233 citedByCount "21" @default.
- W2082703233 countsByYear W20827032332014 @default.
- W2082703233 countsByYear W20827032332015 @default.
- W2082703233 countsByYear W20827032332016 @default.
- W2082703233 countsByYear W20827032332017 @default.
- W2082703233 countsByYear W20827032332018 @default.
- W2082703233 countsByYear W20827032332019 @default.
- W2082703233 countsByYear W20827032332020 @default.
- W2082703233 countsByYear W20827032332021 @default.
- W2082703233 countsByYear W20827032332022 @default.
- W2082703233 countsByYear W20827032332023 @default.
- W2082703233 crossrefType "journal-article" @default.
- W2082703233 hasAuthorship W2082703233A5056884838 @default.
- W2082703233 hasAuthorship W2082703233A5058559078 @default.
- W2082703233 hasAuthorship W2082703233A5071011347 @default.
- W2082703233 hasConcept C127413603 @default.
- W2082703233 hasConcept C185592680 @default.
- W2082703233 hasConcept C192562407 @default.
- W2082703233 hasConcept C2778512257 @default.
- W2082703233 hasConcept C2778746504 @default.
- W2082703233 hasConcept C2780035454 @default.
- W2082703233 hasConcept C42360764 @default.
- W2082703233 hasConcept C43617362 @default.
- W2082703233 hasConcept C501593827 @default.
- W2082703233 hasConcept C55493867 @default.
- W2082703233 hasConcept C71924100 @default.
- W2082703233 hasConcept C98274493 @default.
- W2082703233 hasConceptScore W2082703233C127413603 @default.
- W2082703233 hasConceptScore W2082703233C185592680 @default.
- W2082703233 hasConceptScore W2082703233C192562407 @default.
- W2082703233 hasConceptScore W2082703233C2778512257 @default.
- W2082703233 hasConceptScore W2082703233C2778746504 @default.
- W2082703233 hasConceptScore W2082703233C2780035454 @default.
- W2082703233 hasConceptScore W2082703233C42360764 @default.
- W2082703233 hasConceptScore W2082703233C43617362 @default.
- W2082703233 hasConceptScore W2082703233C501593827 @default.
- W2082703233 hasConceptScore W2082703233C55493867 @default.
- W2082703233 hasConceptScore W2082703233C71924100 @default.
- W2082703233 hasConceptScore W2082703233C98274493 @default.
- W2082703233 hasLocation W20827032331 @default.
- W2082703233 hasOpenAccess W2082703233 @default.
- W2082703233 hasPrimaryLocation W20827032331 @default.
- W2082703233 hasRelatedWork W1976528799 @default.
- W2082703233 hasRelatedWork W2021838179 @default.
- W2082703233 hasRelatedWork W2023345124 @default.
- W2082703233 hasRelatedWork W2036936951 @default.
- W2082703233 hasRelatedWork W2071701226 @default.
- W2082703233 hasRelatedWork W2171276305 @default.
- W2082703233 hasRelatedWork W2392156521 @default.
- W2082703233 hasRelatedWork W2748952813 @default.
- W2082703233 hasRelatedWork W2899084033 @default.
- W2082703233 hasRelatedWork W2516967879 @default.
- W2082703233 hasVolume "257" @default.
- W2082703233 isParatext "false" @default.
- W2082703233 isRetracted "false" @default.
- W2082703233 magId "2082703233" @default.
- W2082703233 workType "article" @default.