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• W2082728345 abstract "The first mAb (OKT3) was approved for the treatment of allograft rejection in 1986, and was all mouse protein. Now virtually all new mAbs are humanized. However, most of the growing numbers of mAbs entering clinical trials are completely human. Two technological advances have made it possible to design all human mAb for the treatment of disease: phage display technology and transgenic mice that express human immunoglobulin genes. For example, adalimumab is a human anti–TNF-α mAb derived from phage-display technology for the treatment of rheumatoid arthritis and psoriatic arthritis. A key advantage of mAb and recombinant protein conjugates is that their properties can be modified, even endowing them with new activities through advances in molecular biology. Even in 1 year, there have been many advances in the use of biologics as therapeutic modalities, especially in autoimmune disease and in the treatment of cancers. More than 150 mAbs are currently in clinical development. Over the next 5 years, we will see the development of designer mAbs for the treatment of a variety of disease processes." @default.
• W2082728345 created "2016-06-24" @default.
• W2082728345 creator A5037734477 @default.
• W2082728345 date "2006-12-01" @default.
• W2082728345 modified "2023-10-14" @default.
• W2082728345 title "Biologic immune modifiers: Trials and tribulations—are we there yet?" @default.
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• W2082728345 doi "https://doi.org/10.1016/j.jaci.2006.09.024" @default.
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