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- W208272837 abstract "This chapter discusses the role of hydroxylated metabolites of phenytoin in dose-dependency. Phenytoin exhibits some unusual pharmacokinetic behavior in laboratory animals and in man. This includes a progressive decrease in plasma half-life as the plasma levels fall, a dependency of plasma half-life upon dosage, an abrupt nonlinear increase in plasma levels of DPH with increasing dosage, a difference in the area under curve for oral and I.V. routes of administration, and a greatly delayed peak in the urinary excretion of the hydroxylated metabolite p-HPPH. DPH plasma levels exhibit a 10 to 20-fold variation in different subjects partly because of genetic variations in hydroxylation capability, enzyme induction, and dose-dependent kinetics. The observations discussed in the chapter demonstrate a dependency of DPH plasma half-life in the Rhesus monkey upon dosage and present the quantitative data on the plasma levels of HPPH." @default.
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- W208272837 date "1977-01-01" @default.
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- W208272837 title "ROLE OF HYDROXYLATED METABOLITES OF PHENYTOIN IN DOSE-DEPENDENCY" @default.
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- W208272837 doi "https://doi.org/10.1016/b978-0-08-021523-5.50071-7" @default.
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