FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082744507> ?p ?o ?g. }

• W2082744507 endingPage "276" @default.
• W2082744507 startingPage "268" @default.
• W2082744507 abstract "Aim Renal afferent arterioles are the effector site for autoregulation of glomerular perfusion and filtration. There is synergistic interaction between angiotensin II (ANG II) and adenosine (Ado) in regulating arteriolar contraction; however, the mechanisms are not clear. In this context, this study investigated the contribution of A1 receptor-dependent and independent signalling mechanisms. Methods Isolated perfused afferent arterioles from transgenic mice (A1+/+ and A1−/−) were used for vascular reactivity studies. Cultured vascular smooth muscle cells (VSMC) were used for phosphorylation studies of signalling proteins that induce arteriolar contraction. Results Maximal arteriolar contraction to ANG II was attenuated in A1−/− (22%) compared with A1+/+ (40%). Simultaneous incubation with low-dose ado (10−8 mol L−1) enhanced ANG II-induced contraction in A1+/+ (58%), but also in A1−/− (42%). An ado transporter inhibitor (NBTI) abolished this synergistic effect in A1−/−, but not in wild-type mice. Incubation with Ado + ANG II increased p38 phosphorylation in aortic VSMC from both genotypes, but treatment with NBTI only blocked phosphorylation in A1−/−. Combination of ANG II + Ado also increased MLC phosphorylation in A1+/+ but not significantly in A1−/−, and NBTI had no effects. In agreement, Ado + ANG II-induced phosphorylation of p38 and MLC in rat pre-glomerular VSMC was not affected by NBTI. However, during pharmacological inhibition of the A1 receptor simultaneous treatment with NBTI reduced phosphorylation of both p38 and MLC to control levels. Conclusion Interaction between ANG II and Ado in VSMC normally involves A1 receptor signalling, but this can be compensated by receptor independent actions that phosphorylate p38 MAPK and MLC." @default.
• W2082744507 created "2016-06-24" @default.
• W2082744507 creator A5025470445 @default.
• W2082744507 creator A5042569559 @default.
• W2082744507 creator A5051910738 @default.
• W2082744507 creator A5073067804 @default.
• W2082744507 creator A5076486841 @default.
• W2082744507 creator A5082064420 @default.
• W2082744507 date "2014-10-09" @default.
• W2082744507 modified "2023-10-15" @default.
• W2082744507 title "Adenosine A1receptor-dependent and independent pathways in modulating renal vascular responses to angiotensin II" @default.
• W2082744507 cites W1970677658 @default.
• W2082744507 cites W1977706612 @default.
• W2082744507 cites W1980993178 @default.
• W2082744507 cites W1987191648 @default.
• W2082744507 cites W2006324925 @default.
• W2082744507 cites W2006489146 @default.
• W2082744507 cites W2011916103 @default.
• W2082744507 cites W2023000258 @default.
• W2082744507 cites W2034500174 @default.
• W2082744507 cites W2080613386 @default.
• W2082744507 cites W2081430737 @default.
• W2082744507 cites W2103814124 @default.
• W2082744507 cites W2110578605 @default.
• W2082744507 cites W2123106426 @default.
• W2082744507 cites W2139320655 @default.
• W2082744507 cites W2140332753 @default.
• W2082744507 cites W2148296520 @default.
• W2082744507 cites W2155072308 @default.
• W2082744507 cites W2165666535 @default.
• W2082744507 cites W2166277435 @default.
• W2082744507 cites W2168009210 @default.
• W2082744507 cites W2168910111 @default.
• W2082744507 cites W2169114428 @default.
• W2082744507 cites W4250593310 @default.
• W2082744507 cites W4251202920 @default.
• W2082744507 doi "https://doi.org/10.1111/apha.12399" @default.
• W2082744507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25251152" @default.
• W2082744507 hasPublicationYear "2014" @default.
• W2082744507 type Work @default.
• W2082744507 sameAs 2082744507 @default.
• W2082744507 citedByCount "7" @default.
• W2082744507 countsByYear W20827445072015 @default.
• W2082744507 countsByYear W20827445072016 @default.
• W2082744507 countsByYear W20827445072017 @default.
• W2082744507 countsByYear W20827445072021 @default.
• W2082744507 crossrefType "journal-article" @default.
• W2082744507 hasAuthorship W2082744507A5025470445 @default.
• W2082744507 hasAuthorship W2082744507A5042569559 @default.
• W2082744507 hasAuthorship W2082744507A5051910738 @default.
• W2082744507 hasAuthorship W2082744507A5073067804 @default.
• W2082744507 hasAuthorship W2082744507A5076486841 @default.
• W2082744507 hasAuthorship W2082744507A5082064420 @default.
• W2082744507 hasConcept C11960822 @default.
• W2082744507 hasConcept C126322002 @default.
• W2082744507 hasConcept C134018914 @default.
• W2082744507 hasConcept C163415756 @default.
• W2082744507 hasConcept C170493617 @default.
• W2082744507 hasConcept C185592680 @default.
• W2082744507 hasConcept C2776991684 @default.
• W2082744507 hasConcept C2779395532 @default.
• W2082744507 hasConcept C2908929049 @default.
• W2082744507 hasConcept C2992686903 @default.
• W2082744507 hasConcept C71924100 @default.
• W2082744507 hasConcept C86803240 @default.
• W2082744507 hasConcept C95444343 @default.
• W2082744507 hasConcept C98274493 @default.
• W2082744507 hasConceptScore W2082744507C11960822 @default.
• W2082744507 hasConceptScore W2082744507C126322002 @default.
• W2082744507 hasConceptScore W2082744507C134018914 @default.
• W2082744507 hasConceptScore W2082744507C163415756 @default.
• W2082744507 hasConceptScore W2082744507C170493617 @default.
• W2082744507 hasConceptScore W2082744507C185592680 @default.
• W2082744507 hasConceptScore W2082744507C2776991684 @default.
• W2082744507 hasConceptScore W2082744507C2779395532 @default.
• W2082744507 hasConceptScore W2082744507C2908929049 @default.
• W2082744507 hasConceptScore W2082744507C2992686903 @default.
• W2082744507 hasConceptScore W2082744507C71924100 @default.
• W2082744507 hasConceptScore W2082744507C86803240 @default.
• W2082744507 hasConceptScore W2082744507C95444343 @default.
• W2082744507 hasConceptScore W2082744507C98274493 @default.
• W2082744507 hasFunder F4320321033 @default.
• W2082744507 hasFunder F4320322169 @default.
• W2082744507 hasIssue "1" @default.
• W2082744507 hasLocation W20827445071 @default.
• W2082744507 hasLocation W20827445072 @default.
• W2082744507 hasOpenAccess W2082744507 @default.
• W2082744507 hasPrimaryLocation W20827445071 @default.
• W2082744507 hasRelatedWork W1965943749 @default.
• W2082744507 hasRelatedWork W1971613811 @default.
• W2082744507 hasRelatedWork W1997650562 @default.
• W2082744507 hasRelatedWork W2047925791 @default.
• W2082744507 hasRelatedWork W2063619316 @default.
• W2082744507 hasRelatedWork W2091193686 @default.
• W2082744507 hasRelatedWork W2137237120 @default.
• W2082744507 hasRelatedWork W2151139437 @default.
• W2082744507 hasRelatedWork W2162471541 @default.
• W2082744507 hasRelatedWork W2905993336 @default.

• next