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- W2082755734 abstract "Cancer, an unrestrained proliferation of cells, is one of the lead cause of death. Nearly 12.5 million people are diagnosed with cancer worldwide, 7.5 million people die of which 2.5 million cases are from India. Major cause for cancer is restriction of programmed cell death (apoptosis). Multiple signaling pathways regulate apoptosis. Bcl-2 (B - Cell Lymphomas-2) family proteins play a vital role as central regulators of apoptosis. Bcl-2L10, a novel anti-apoptotic protein, blocks apoptosis by mitochondrial dependent mechanism. The present study evaluates the 3D structure of Bcl-2L10 protein using homology modeling and aims to understand plausible functional and binding interactions between Bcl-2L10 with BH3 domain of BAX using protein - protein docking. The docking studies show binding of BH3 domain at Lys 110, Trp-111, Pro-115, Glu-119 and Asp-127 in the groove of BH 1, 2 and 3 domains of Bcl-2L10. Heterodimerization of anti-apoptotic Bcl-2 and BH3 domain of pro-apoptotic Bcl-2 proteins instigates apoptosis. Profound understanding of Bcl-2 pathway may prove useful in identification of future therapeutic targets for cancer." @default.
- W2082755734 created "2016-06-24" @default.
- W2082755734 creator A5001501386 @default.
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- W2082755734 creator A5056057115 @default.
- W2082755734 creator A5059311635 @default.
- W2082755734 date "2010-12-01" @default.
- W2082755734 modified "2023-10-16" @default.
- W2082755734 title "Homology Modeling and Docking Studies of Human Bcl-2L10 Protein" @default.
- W2082755734 cites W1745634660 @default.
- W2082755734 cites W1964136077 @default.
- W2082755734 cites W1965217295 @default.
- W2082755734 cites W1966041739 @default.
- W2082755734 cites W1969007008 @default.
- W2082755734 cites W1972362308 @default.
- W2082755734 cites W1975505218 @default.
- W2082755734 cites W1977258127 @default.
- W2082755734 cites W1978883524 @default.
- W2082755734 cites W1980374511 @default.
- W2082755734 cites W1980727670 @default.
- W2082755734 cites W1980792888 @default.
- W2082755734 cites W1986191025 @default.
- W2082755734 cites W1986388339 @default.
- W2082755734 cites W1991450922 @default.
- W2082755734 cites W1992947847 @default.
- W2082755734 cites W1995794152 @default.
- W2082755734 cites W2004139620 @default.
- W2082755734 cites W2004228538 @default.
- W2082755734 cites W2005109042 @default.
- W2082755734 cites W2008845432 @default.
- W2082755734 cites W2009158642 @default.
- W2082755734 cites W2009382824 @default.
- W2082755734 cites W2013673509 @default.
- W2082755734 cites W2014985938 @default.
- W2082755734 cites W2015026994 @default.
- W2082755734 cites W2015642465 @default.
- W2082755734 cites W2015879631 @default.
- W2082755734 cites W2017807973 @default.
- W2082755734 cites W2025542553 @default.
- W2082755734 cites W2039117441 @default.
- W2082755734 cites W2039990656 @default.
- W2082755734 cites W2045110975 @default.
- W2082755734 cites W2047468595 @default.
- W2082755734 cites W2051931326 @default.
- W2082755734 cites W2055043387 @default.
- W2082755734 cites W2057662062 @default.
- W2082755734 cites W2058264793 @default.
- W2082755734 cites W2065283382 @default.
- W2082755734 cites W2066142272 @default.
- W2082755734 cites W2067227802 @default.
- W2082755734 cites W2068745373 @default.
- W2082755734 cites W2069663555 @default.
- W2082755734 cites W2071484166 @default.
- W2082755734 cites W2071486470 @default.
- W2082755734 cites W2072618201 @default.
- W2082755734 cites W2072757401 @default.
- W2082755734 cites W2075065864 @default.
- W2082755734 cites W2076542620 @default.
- W2082755734 cites W2077776336 @default.
- W2082755734 cites W2079592758 @default.
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- W2082755734 cites W2084466582 @default.
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- W2082755734 cites W2108067237 @default.
- W2082755734 cites W2111941604 @default.
- W2082755734 cites W2114520383 @default.
- W2082755734 cites W2129454543 @default.
- W2082755734 cites W2132717858 @default.
- W2082755734 cites W2133712572 @default.
- W2082755734 cites W2134413058 @default.
- W2082755734 cites W2137015675 @default.
- W2082755734 cites W2138227733 @default.
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- W2082755734 doi "https://doi.org/10.1080/07391102.2010.10507367" @default.
- W2082755734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20919753" @default.
- W2082755734 hasPublicationYear "2010" @default.
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