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- W2082762726 abstract "Genotoxicity and cytotoxic effects of eight new nitrothiophenic compounds with trypanocidal activity were determined by means of the SOS Chromotest assay. Our results indicate that all nitro compounds with one aromatic ring in the R group were genotoxic without and with metabolic activation. The compounds with two aromatic rings in the R group, except for indazol-1-yl, were strongly cytotoxic but they were unable to induce SOS functions without metabolic activation. However, after metabolic activation no cytotoxic effect was observed for these compounds. The role of the nitroreductases to explain the different genotoxic responses of these nitrothiophenic derivatives is discussed." @default.
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- W2082762726 date "1994-03-01" @default.
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- W2082762726 title "The SOS function-inducing activity of the new nitrothiophenic derivatives in Escherichia coli" @default.
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- W2082762726 doi "https://doi.org/10.1016/0027-5107(94)90229-1" @default.
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