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- W2082763419 abstract "In 1999, the RALES study found a significant reduction in death and hospitalization associated with spironolactone, in patients with LVEF ≤35% and severe functional impairment (NYHA class III–IV) [ [1] Pitt B. Zannad F. Remme W.J. et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. Sep 2 1999; 341: 709-717 Crossref PubMed Scopus (7514) Google Scholar ]. In 2011, the EMPHASIS-HF study showed that the administration of a new selective mineralocorticoid receptor (MR) antagonist, eplerenone, was associated with risk reduction in a broad spectrum of cardiovascular adverse events, in patients with systolic HF and mild symptoms (NYHA class II) [ [2] Zannad F. McMurray J.J. Krum H. et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. Jan 6 2011; 364: 11-21 Crossref PubMed Scopus (2116) Google Scholar ]. Because substantial differences exist between both populations in terms of the baseline heart failure therapy (only 11% were on betablockers in RALES), caution is advised when directly comparing these trial results. In addition, spironolactone and eplerenone have different selectivity for the MR, as well as differences in hormonal and metabolic effects, which provide eplerenone with a better metabolic profile [ [3] Struthers A. Krum H. Williams G.H. A comparison of the aldosterone-blocking agents eplerenone and spironolactone. Clin Cardiol. Apr 2008; 31: 153-158 Crossref PubMed Scopus (167) Google Scholar ]. Therefore, after the publication of the results of EMPHASIS, a question remained as to whether both MR antagonists have the same benefits in patients with mild systolic HF." @default.
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- W2082763419 date "2013-10-01" @default.
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- W2082763419 title "Spironolactone in mild chronic heart failure: Insights from a propensity-matched analysis of the MUSIC study cohort" @default.
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- W2082763419 doi "https://doi.org/10.1016/j.ijcard.2013.06.103" @default.
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