Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082783144> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2082783144 endingPage "498" @default.
- W2082783144 startingPage "493" @default.
- W2082783144 abstract "Protein kinase CK2 is an unfavorable pronostic marker in several cancers and has consequently emerged as a relevant therapeutic target. Several classes of ATP-competitive inhibitors have been identified, showing variable effectiveness. The molecular architecture of this multisubunit enzyme could offer alternative strategies to develop small molecule inhibitors targeting different surfaces of the kinase. Polyoxometalates were identified as original CK2 inhibitors targeting key structural elements located outside the active site. In addition, the CK2 subunit interface represents an exosite distinct from the catalytic cavity that can be targeted by peptides or small molecules to achieve functional effects." @default.
- W2082783144 created "2016-06-24" @default.
- W2082783144 creator A5001685428 @default.
- W2082783144 creator A5021209623 @default.
- W2082783144 creator A5074951005 @default.
- W2082783144 date "2010-03-01" @default.
- W2082783144 modified "2023-09-25" @default.
- W2082783144 title "Structure-based discovery of small molecules targeting different surfaces of protein-kinase CK2" @default.
- W2082783144 cites W1487134985 @default.
- W2082783144 cites W1968329569 @default.
- W2082783144 cites W1969543057 @default.
- W2082783144 cites W1973180272 @default.
- W2082783144 cites W1978265006 @default.
- W2082783144 cites W1989468344 @default.
- W2082783144 cites W2007909244 @default.
- W2082783144 cites W2010839009 @default.
- W2082783144 cites W2016011980 @default.
- W2082783144 cites W2023892197 @default.
- W2082783144 cites W2052420692 @default.
- W2082783144 cites W2056744944 @default.
- W2082783144 cites W2058739448 @default.
- W2082783144 cites W2060094491 @default.
- W2082783144 cites W2064284165 @default.
- W2082783144 cites W2069647544 @default.
- W2082783144 cites W2070447276 @default.
- W2082783144 cites W2086191771 @default.
- W2082783144 cites W2091297863 @default.
- W2082783144 cites W2146672317 @default.
- W2082783144 cites W2148990487 @default.
- W2082783144 cites W2151575257 @default.
- W2082783144 cites W2156232082 @default.
- W2082783144 cites W2168638540 @default.
- W2082783144 cites W2172171459 @default.
- W2082783144 doi "https://doi.org/10.1016/j.bbapap.2009.09.003" @default.
- W2082783144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19766740" @default.
- W2082783144 hasPublicationYear "2010" @default.
- W2082783144 type Work @default.
- W2082783144 sameAs 2082783144 @default.
- W2082783144 citedByCount "43" @default.
- W2082783144 countsByYear W20827831442012 @default.
- W2082783144 countsByYear W20827831442013 @default.
- W2082783144 countsByYear W20827831442014 @default.
- W2082783144 countsByYear W20827831442015 @default.
- W2082783144 countsByYear W20827831442016 @default.
- W2082783144 countsByYear W20827831442017 @default.
- W2082783144 countsByYear W20827831442018 @default.
- W2082783144 countsByYear W20827831442019 @default.
- W2082783144 countsByYear W20827831442020 @default.
- W2082783144 countsByYear W20827831442021 @default.
- W2082783144 countsByYear W20827831442022 @default.
- W2082783144 crossrefType "journal-article" @default.
- W2082783144 hasAuthorship W2082783144A5001685428 @default.
- W2082783144 hasAuthorship W2082783144A5021209623 @default.
- W2082783144 hasAuthorship W2082783144A5074951005 @default.
- W2082783144 hasConcept C104292427 @default.
- W2082783144 hasConcept C104317684 @default.
- W2082783144 hasConcept C161624437 @default.
- W2082783144 hasConcept C181199279 @default.
- W2082783144 hasConcept C184235292 @default.
- W2082783144 hasConcept C185592680 @default.
- W2082783144 hasConcept C55493867 @default.
- W2082783144 hasConcept C70721500 @default.
- W2082783144 hasConcept C86803240 @default.
- W2082783144 hasConcept C95444343 @default.
- W2082783144 hasConcept C97029542 @default.
- W2082783144 hasConceptScore W2082783144C104292427 @default.
- W2082783144 hasConceptScore W2082783144C104317684 @default.
- W2082783144 hasConceptScore W2082783144C161624437 @default.
- W2082783144 hasConceptScore W2082783144C181199279 @default.
- W2082783144 hasConceptScore W2082783144C184235292 @default.
- W2082783144 hasConceptScore W2082783144C185592680 @default.
- W2082783144 hasConceptScore W2082783144C55493867 @default.
- W2082783144 hasConceptScore W2082783144C70721500 @default.
- W2082783144 hasConceptScore W2082783144C86803240 @default.
- W2082783144 hasConceptScore W2082783144C95444343 @default.
- W2082783144 hasConceptScore W2082783144C97029542 @default.
- W2082783144 hasFunder F4320320883 @default.
- W2082783144 hasFunder F4320323911 @default.
- W2082783144 hasIssue "3" @default.
- W2082783144 hasLocation W20827831441 @default.
- W2082783144 hasLocation W20827831442 @default.
- W2082783144 hasOpenAccess W2082783144 @default.
- W2082783144 hasPrimaryLocation W20827831441 @default.
- W2082783144 hasRelatedWork W1550996414 @default.
- W2082783144 hasRelatedWork W2025794474 @default.
- W2082783144 hasRelatedWork W2059541720 @default.
- W2082783144 hasRelatedWork W2062471223 @default.
- W2082783144 hasRelatedWork W2094486721 @default.
- W2082783144 hasRelatedWork W2325330181 @default.
- W2082783144 hasRelatedWork W2401494639 @default.
- W2082783144 hasRelatedWork W2415377742 @default.
- W2082783144 hasRelatedWork W2913892166 @default.
- W2082783144 hasRelatedWork W996538528 @default.
- W2082783144 hasVolume "1804" @default.
- W2082783144 isParatext "false" @default.
- W2082783144 isRetracted "false" @default.
- W2082783144 magId "2082783144" @default.
- W2082783144 workType "article" @default.