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- W2082798134 abstract "• SUDEP is the leading cause of death in epileptic patients. • Multiple mechanisms are thought to be involved, including respiratory dysfunction. • Serotonin is critical for control of breathing, chemoreception and arousal. • Defects in the serotonin system could be a contributing factor to SUDEP. Sudden unexplained death in epilepsy (SUDEP) is the cause of premature death of up to 17% of all patients with epilepsy and as many as 50% with chronic refractory epilepsy. However, SUDEP is not widely recognized to exist. The etiology of SUDEP remains unclear, but growing evidence points to peri-ictal respiratory, cardiac, or autonomic nervous system dysfunction. How seizures affect these systems remains uncertain. Here we focus on respiratory mechanisms believed to underlie SUDEP. We highlight clinical evidence that indicates peri-ictal hypoxemia occurs in a large percentage of patients due to central apnea, and identify the proposed anatomical regions of the brain governing these responses. In addition, we discuss animal models used to study peri-ictal respiratory depression. We highlight the role 5-HT neurons play in respiratory control, chemoreception, and arousal. Finally, we discuss the evidence that 5-HT deficits contribute to SUDEP and sudden infant death syndrome and the striking similarities between the two." @default.
- W2082798134 created "2016-06-24" @default.
- W2082798134 creator A5029039226 @default.
- W2082798134 creator A5033922320 @default.
- W2082798134 creator A5037071752 @default.
- W2082798134 creator A5052942532 @default.
- W2082798134 creator A5062444876 @default.
- W2082798134 date "2013-11-01" @default.
- W2082798134 modified "2023-10-03" @default.
- W2082798134 title "Sudden unexpected death in epilepsy: Fatal post-ictal respiratory and arousal mechanisms" @default.
- W2082798134 cites W1480458656 @default.
- W2082798134 cites W1480524175 @default.
- W2082798134 cites W1483860098 @default.
- W2082798134 cites W1516480924 @default.
- W2082798134 cites W1524327358 @default.
- W2082798134 cites W1533657503 @default.
- W2082798134 cites W1538959478 @default.
- W2082798134 cites W1585081884 @default.
- W2082798134 cites W1590194551 @default.
- W2082798134 cites W1592034102 @default.
- W2082798134 cites W1603973080 @default.
- W2082798134 cites W1606835851 @default.
- W2082798134 cites W1608846710 @default.
- W2082798134 cites W1632222318 @default.
- W2082798134 cites W1670158471 @default.
- W2082798134 cites W1794342835 @default.
- W2082798134 cites W1816316326 @default.
- W2082798134 cites W1963533150 @default.
- W2082798134 cites W1964625207 @default.
- W2082798134 cites W1965070710 @default.
- W2082798134 cites W1968154246 @default.
- W2082798134 cites W1974504450 @default.
- W2082798134 cites W1975190957 @default.
- W2082798134 cites W1977259014 @default.
- W2082798134 cites W1980211110 @default.
- W2082798134 cites W1983780510 @default.
- W2082798134 cites W1986551515 @default.
- W2082798134 cites W1990991409 @default.
- W2082798134 cites W1993608941 @default.
- W2082798134 cites W1993893814 @default.
- W2082798134 cites W1994145018 @default.
- W2082798134 cites W2004997082 @default.
- W2082798134 cites W2007569082 @default.
- W2082798134 cites W2009969708 @default.
- W2082798134 cites W2012700518 @default.
- W2082798134 cites W2015181753 @default.
- W2082798134 cites W2017089787 @default.
- W2082798134 cites W2018761568 @default.
- W2082798134 cites W2019103767 @default.
- W2082798134 cites W2027075064 @default.
- W2082798134 cites W2031961607 @default.
- W2082798134 cites W2036233413 @default.
- W2082798134 cites W2039026888 @default.
- W2082798134 cites W2039596041 @default.
- W2082798134 cites W2049666590 @default.
- W2082798134 cites W2051741307 @default.
- W2082798134 cites W2055135519 @default.
- W2082798134 cites W2055499340 @default.
- W2082798134 cites W2057352813 @default.
- W2082798134 cites W2061504052 @default.
- W2082798134 cites W2062633223 @default.
- W2082798134 cites W2064628148 @default.
- W2082798134 cites W2069048858 @default.
- W2082798134 cites W2071629944 @default.
- W2082798134 cites W2071944453 @default.
- W2082798134 cites W2073264109 @default.
- W2082798134 cites W2074605068 @default.
- W2082798134 cites W2078644401 @default.
- W2082798134 cites W2079476861 @default.
- W2082798134 cites W2083974908 @default.
- W2082798134 cites W2087547939 @default.
- W2082798134 cites W2088072875 @default.
- W2082798134 cites W2088249036 @default.
- W2082798134 cites W2092880730 @default.
- W2082798134 cites W2093122909 @default.
- W2082798134 cites W2095497070 @default.
- W2082798134 cites W2100857624 @default.
- W2082798134 cites W2102428405 @default.
- W2082798134 cites W2109124126 @default.
- W2082798134 cites W2109831177 @default.
- W2082798134 cites W2114444638 @default.
- W2082798134 cites W2118516203 @default.
- W2082798134 cites W2119243552 @default.
- W2082798134 cites W2121692105 @default.
- W2082798134 cites W2125409227 @default.
- W2082798134 cites W2131079705 @default.
- W2082798134 cites W2131979832 @default.
- W2082798134 cites W2136520229 @default.
- W2082798134 cites W2144858158 @default.
- W2082798134 cites W2145313511 @default.
- W2082798134 cites W2146506622 @default.
- W2082798134 cites W2156672854 @default.
- W2082798134 cites W2157152005 @default.
- W2082798134 cites W2157851792 @default.
- W2082798134 cites W2159213224 @default.
- W2082798134 cites W2167285873 @default.
- W2082798134 cites W2233793390 @default.
- W2082798134 cites W2414501936 @default.