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- W2082804517 abstract "The effects of the thromboxane‐receptor antagonist AH 23848 were investigated on isolated feline basilar arteries (BA). AH 23848 (10 ‐6 mol l ‐1 ) had no effect on contractions induced by 5‐hydroxytryptamine or potassium, whereas the drug (10 ‐8 ‐10 ‐6 mol 1 ‐1 ) induced a parallel shift to the right in contractions induced by the thromboxane A 2 mimic U46619. There was no depression of the maximum contraction, indicating competitive antagonism. The Schild plot revealed a slope index of unity with a pA 2 value of 8.46. In contrast, 10 ‐6 mol l ‐1 AH 23848 depressed the maximum PGF 2α ‐induced contraction significantly from 100% to 13%. U46619 was able to induce a contraction amounting to 98 % if the drug was added on top of the PGF 2α ‐induced contraction in the presence of 10 ‐6 mol l ‐1 AH 23848. The results provide strong support for previous suggestions that prostanoid‐induced contractions in the feline BA are mediated by two receptor subtypes, one of which can be classified as a thromboxane‐sensitive (TP) receptor." @default.
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- W2082804517 date "1988-08-01" @default.
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- W2082804517 title "Further characterization of the contraction-mediating prostanoid receptors in feline cerebral arteries. Effects of the thromboxane-receptor antagonist AH 23848" @default.
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- W2082804517 doi "https://doi.org/10.1111/j.1748-1716.1988.tb08436.x" @default.
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